ArticleBMC anesthesiology2002
Single-dose rofecoxib for acute postoperative pain in adults: a quantitative systematic review.
Article in BMC anesthesiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Single dose oral rofecoxib for acute postoperative pain in adults.The Cochrane database of systematic reviews · 2009Pooled it
- Analgesics for pain after traumatic or orthopaedic surgery: what is the evidence--a systematic review.European journal of clinical pharmacology · 2006Pooled it
- Single dose oral naproxen and naproxen sodium for acute postoperative pain.The Cochrane database of systematic reviews · 2004Pooled it
- Perioperative celecoxib administration for pain management after total knee arthroplasty - a randomized, controlled study.BMC musculoskeletal disorders · 2008Trial
- [Postoperative analgesia with rofecoxib. How effective is the preoperative application of a 25 mg dose?].Schmerz (Berlin, Germany) · 2004Trial
- Comparison of the Analgesic Effect of Paracetamol and Magnesium Sulfate during Surgeries.World journal of plastic surgery · 2016Article
- Intravenous paracetamol for postoperative analgesia in laparoscopic cholecystectomy.Anesthesiology and pain medicine · 2013Article
- Rheumatology and musculoskeletal medicine.The British journal of general practice : the journal of the Royal College of General Practitioners · 2004Review
- [Non-opioid analgesics for perioperative pain therapy. Risks and rational basis for use].Der Anaesthesist · 2004Review
- Individual patient meta-analysis of single-dose rofecoxib in postoperative pain.BMC anesthesiology · 2004Article
- Single-dose oral naproxen for acute postoperative pain: a quantitative systematic review.BMC anesthesiology · 2003Article
- Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review.BMC anesthesiology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRofecoxib is a cyclo-oxygenase 2 selective inhibitor. This systematic review of rofecoxib in acute pain examined studies in adults of analgesic efficacy over six hours, the amount and quality of the evidence on extended duration of analgesia, and the quality and quantity of evidence on adverse events.
methodsCochrane Library (issue 4, 2001), Biological Abstracts (March 2002), MEDLINE (March 2002) and PubMed (March 2002) were searched using rofecoxib as a free text term. The area under the pain relief versus time curve was dichotomized using validated equations to derive the proportion of patients on rofecoxib 50 mg or placebo with at least 50% pain relief over six hours. This was used to calculate the number needed to treat for at least 50% pain relief over six hours for rofecoxib compared with placebo. Information on duration of analgesia and adverse events was also collected.
resultsFive included trials investigated 1,118 patients, of whom 211 received placebo and 464 received rofecoxib 50 mg. The NNT for rofecoxib 50 mg was 2.3 (95% confidence interval 2.0 to 2.6). The weighted mean remedication time was 1.9 hours for placebo (126 patients), 7.4 hours for ibuprofen 400 mg (97 patients) and 13.6 hours for rofecoxib 50 mg (322 patients).
conclusionRofecoxib at 2-4 times the standard daily dose for chronic pain is an effective single dose oral analgesic in acute pain. Limitations in trial reporting constrain conclusions about longer duration of analgesia and adverse event profile.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.