ArticleThe Journal of physiology2002
Photolysis of caged cyclic AMP in the ciliary cytoplasm of the newt olfactory receptor cell.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Olfactory cilia, regulation and control of olfaction.Physiological reports · 2024Review
- Segregation of Ca2+ signaling in olfactory signal transduction.The Journal of general physiology · 2023Article
- Olfactory marker protein interacts with adenosine nucleotide derivatives.Biochemistry and biophysics reports · 2021Article
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons.Nature communications · 2020Article
- Suppression of olfactory signal transduction by insecticides.NPJ science of food · 2019Article
- Second messenger molecules have a limited spread in olfactory cilia.The Journal of general physiology · 2018Article
- Article
- Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.PloS one · 2014Article
- 2,4,6-trichloroanisole is a potent suppressor of olfactory signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A dynamical feedback model for adaptation in the olfactory transduction pathway.Biophysical journal · 2012Article
- Chemical structures of odorants that suppress ion channels in the olfactory receptor cell.The journal of physiological sciences : JPS · 2011Article
- Review
- Cellular and molecular Ca2+ microdomains in olfactory cilia support low signaling amplification of odor transduction.The European journal of neuroscience · 2010Article
- Article
- Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons.Journal of computational neuroscience · 2009Article
- Mechanism of olfactory masking in the sensory cilia.The Journal of general physiology · 2009Article
- Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Fast adaptation in mouse olfactory sensory neurons does not require the activity of phosphodiesterase.The Journal of general physiology · 2006Article
- Mechanism of signal amplification in the olfactory sensory cilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of cyclic nucleotide monophosphate (cNMP) in the ciliary cytoplasm of the olfactory receptor cell were examined by using photolysis of caged cNMP loaded from the whole-cell patch clamp pipette. Illumination of the cilia induced an inward current at -50 mV. The current amplitude was voltage dependent and the polarity was reversed at +10 mV. The amplitude of the light-induced current was dependent on both light intensity and duration. The intensity-response relation was fitted well by the Hill equation with a coefficient (n(H)) of 4.99 +/- 2.66 (mean +/- S.D., n = 19) and the duration-response relation with a coefficient of 4.03 +/- 1.43 (n = 17). The activation time course of adenylyl cyclase was estimated by comparing the light-induced response with the odorant-induced response. Adenylyl cyclase was activated approximately 260 ms later from the onset of the odorant-stimulation. The light-induced current developed very sharply. This could be explained by the sequential openings of cAMP-gated and Ca2+-activated Cl- channels. At +100 mV, where Ca2+ influx is expected to be very small, the current rising phase became less steep. When the cells were stimulated by long steps of either odour or light, the odorant-induced current showed stronger decay than the light-induced response. This observation suggests that the molecular system regulating desensitization is situated upstream of cAMP production.
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