ArticleThe Journal of physiology2002
Voltage-dependent inward currents of interstitial cells of Cajal from murine colon and small intestine.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 90 citations in OpenAlex.
- Regulation of Autonomic Motility in Human Gastric Muscle and the Gastroepiploic Artery by Stretch and pH.Journal of muscle research and cell motility · 2025Article
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- Plasticity of colonic enteric nervous system following spinal cord injury in male and female rats.Neurogastroenterology and motility · 2023Article
- Hyperpolarization-activated cyclic nucleotide-gated channels working as pacemaker channels in colonic interstitial cells of Cajal.Journal of cellular and molecular medicine · 2022Article
- Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- A novel intramuscular Interstitial Cell of Cajal is a candidate for generating pacemaker activity in the mouse internal anal sphincter.Scientific reports · 2020Article
- CaThe Journal of physiology · 2019Article
- Activation of Ca(2+) -activated Cl(-) channel ANO1 by localized Ca(2+) signals.The Journal of physiology · 2016Review
- Electrophysiological and Mechanical Characteristics in Human Ileal Motility: Recordings of Slow Waves Conductions and Contractions, In vitro.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2015Article
- Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury.Journal of neurogastroenterology and motility · 2015Article
- Effects of gap junction inhibition on contraction waves in the murine small intestine in relation to coupled oscillator theory.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- The significance of interstitial cells in neurogastroenterology.Journal of neurogastroenterology and motility · 2014Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Computational modeling of anoctamin 1 calcium-activated chloride channels as pacemaker channels in interstitial cells of Cajal.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Expression and function of a T-type Ca2+ conductance in interstitial cells of Cajal of the murine small intestine.American journal of physiology. Cell physiology · 2014Article
- Targeting ion channels for the treatment of gastrointestinal motility disorders.Therapeutic advances in gastroenterology · 2012Article
- Biophysically based modeling of the interstitial cells of cajal: current status and future perspectives.Frontiers in physiology · 2011Article
- Article
- T-type Ca(2+) channel modulation by otilonium bromide.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Electrical slow waves in gastrointestinal (GI) muscles are generated by pacemaker cells, known as interstitial cells of Cajal (ICC). The pacemaker conductance is regulated by periodic release of Ca2+ from inositol 1,4,5-trisphosphate (IP(3)) receptor-operated stores, but little is known about how slow waves are actively propagated. We investigated voltage-dependent Ca2+ currents in cultured ICC from the murine colon and small intestine. ICC, identified by kit immunohistochemistry, were spontaneously active under current clamp and generated transient inward (pacemaker) currents under voltage clamp. Depolarization activated inward currents due to entry of Ca2+. Nicardipine (1 microM) blocked only half of the voltage-dependent inward current. After nicardipine, there was a shift in the potential at which peak current was obtained (-15 mV), and negative shifts in the voltage dependence of activation and inactivation of the remaining voltage-dependent inward current. The current that was resistant to dihydropyridine (I(VDDR)) displayed kinetics, ion selectivity and pharmacology that differed from dihydropyridine-sensitive Ca2+ currents. I(VDDR) was increased by elevating extracellular Ca2+ from 2 to 10 mM, and this caused a +30 mV shift in reversal potential. I(VDDR) was blocked by Ni2+ (100 microM) or mebefradil (1 microM) but was not affected by blockers of N-, P- or Q-type Ca2+ channels. Equimolar replacement of Ca2+ with Ba2+ reduced I(VDDR) without effects on inactivation kinetics. BayK8644 had significantly less effect on I(VDDR) than on I(VDIC). In summary, two components of inward Ca2+ current were resolved in ICC of murine small intestine and colon. Since slow waves persist in the presence of dihydropyridines, the dyhydropyridine-resistant component of inward current may contribute to slow wave propagation.
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