ReviewJournal of cellular and molecular medicine
Apolipoprotein E: a major piece in the Alzheimer's disease puzzle.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Lipidome disruption in Alzheimer's disease brain: detection, pathological mechanisms, and therapeutic implications.Molecular neurodegeneration · 2025Review
- Physical Activity Moderates the Relationship between Cardiovascular Disease Risk Burden and Cognition in Older Adults.Neuroepidemiology · 2025Article
- Myelin Lipid Alterations in Neurodegenerative Diseases: Landscape and Pathogenic Implications.Antioxidants & redox signaling · 2024Review
- Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol.Frontiers in cellular neuroscience · 2024Article
- Selective protein aggregation confines and inhibits endotoxins in wounds: Linking host defense to amyloid formation.iScience · 2023Article
- Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease.Neurobiology of disease · 2020Review
- A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study.International journal of geriatric psychiatry · 2019Article
- Physical Activity: A Viable Way to Reduce the Risks of Mild Cognitive Impairment, Alzheimer's Disease, and Vascular Dementia in Older Adults.Brain sciences · 2017Review
- Novel advances in shotgun lipidomics for biology and medicine.Progress in lipid research · 2016Review
- Apolipoprotein E alleles in Cuban patients with mild cognitive impairment.American journal of Alzheimer's disease and other dementias · 2014Article
- A non-invasive, rapid method to genotype late-onset Alzheimer's disease-related apolipoprotein E gene polymorphisms.Neural regeneration research · 2014Article
- HFE gene variants, iron, and lipids: a novel connection in Alzheimer's disease.Frontiers in pharmacology · 2014Review
- Dementia Risk and Financial Decision Making by Older Households: The Impact of Information.Journal of human capital · 2013Article
- Association of cardiovascular burden with mobility limitation among elderly people: a population-based study.PloS one · 2013Article
- Apolipoproteins and amyloid fibril formation in atherosclerosis.Protein & cell · 2011Review
- A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution.Proteins · 2011Article
- The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice.Neuroscience · 2010Article
- Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease.Biochimica et biophysica acta · 2010Review
- Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats.Physiology & behavior · 2009Article
- Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro.Brain pathology (Zurich, Switzerland) · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a complex neurodegenerative disorder with multiple etiologies. The presence of the E4 isoform of apolipoprotein E (apoE) has been shown to increase the risk and to decrease the age of onset for AD and is the major susceptibility factor known for the disease. ApoE4 has been shown to intensify all the biochemical disturbances characteristic of AD, including beta amyloid (Abeta) deposition, tangle formation, neuronal cell death, oxidative stress, synaptic plasticity and dysfunctions of lipid homeostasis and cholinergic signalling. In contrast, other apoE isoforms are protective. Here we review and discuss these major hypotheses of the apoE4-AD association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.