ReviewJournal of cellular and molecular medicine
Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations.Cell death & disease · 2025Review
- mTORC1-Dependent Protein and Parkinson's Disease: A Mendelian Randomization Study.Brain sciences · 2023Article
- Translation ofFrontiers in molecular biosciences · 2023Review
- Impact of Hydrogen Peroxide on Protein Synthesis in Yeast.Antioxidants (Basel, Switzerland) · 2021Review
- Molecular Characterization of Primary Human Astrocytes Using Digital Gene Expression Analysis.Korean journal of neurotrauma · 2019Article
- Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines.Scientific reports · 2018Article
- Article
- Musashi mediates translational repression of the Drosophila hypoxia inducible factor.Nucleic acids research · 2016Article
- The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells.Genes & diseases · 2016Article
- Translational Control during Calicivirus Infection.Viruses · 2016Review
- Article
- A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5'UTRs of Selected Tumor Suppressors.PloS one · 2016Article
- A quantitative proteomics analysis of MCF7 breast cancer stem and progenitor cell populations.Proteomics · 2015Article
- Murine norovirus 1 (MNV1) replication induces translational control of the host by regulating eIF4E activity during infection.The Journal of biological chemistry · 2015Article
- Target proteomic profiling of frozen pancreatic CD24+ adenocarcinoma tissues by immuno-laser capture microdissection and nano-LC-MS/MS.Journal of proteome research · 2013Article
- Regulation of Translation Initiation under Biotic and Abiotic Stresses.International journal of molecular sciences · 2013Article
- Analysis of genome-wide changes in the translatome of Arabidopsis seedlings subjected to heat stress.PloS one · 2013Article
- Regulation of Translation Initiation under Abiotic Stress Conditions in Plants: Is It a Conserved or Not so Conserved Process among Eukaryotes?Comparative and functional genomics · 2012Article
- Protein phosphatase 2A promotes endothelial survival via stabilization of translational inhibitor 4E-BP1 following exposure to tumor necrosis factor-α.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.Parkinson's disease · 2011Article
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1 author.
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Abstract
Several mechanisms have been identified by which protein synthesis may be regulated during the response of mammalian cells to physiological stresses and conditions that induce apoptotic cell death (reviewed in Clemens et al., Cell Death and Differentiation 7, 603-615, 2000). Recent developments allow us to up-date this analysis and in this article I concentrate on one particular aspect of this regulation that has not previously been reviewed in depth in relation to apoptosis, viz. the control of the initiation of protein synthesis by eukaryotic initiation factor eIF4E and the eIF4E binding proteins (4E-BPs). Changes in the state of phosphorylation of the 4E-BPs and in the extent of their association with eIF4E occur at an early stage in the response of cells to apoptotic inducers. The review discusses the mechanisms by which these events are regulated and the significance of the changes for the control of protein synthesis, cell proliferation and cell survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.