ArticleThe EMBO journal2002
R-loop-dependent rolling-circle replication and a new model for DNA concatemer resolution by mitochondrial plasmid mp1.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- What we know so far and what we can expect next: A molecular investigation of plant parasitism.Genetics and molecular biology · 2024Article
- Review
- DNA Repair and the Stability of the Plant Mitochondrial Genome.International journal of molecular sciences · 2020Review
- Complete Sequence, Multichromosomal Architecture and Transcriptome Analysis of theInternational journal of molecular sciences · 2019Article
- Multiple consecutive initiation of replication producing novel brush-like intermediates at the termini of linear viral dsDNA genomes with hairpin ends.Nucleic acids research · 2016Article
- Homologous Recombination Repair Factors Rad51 and BRCA1 Are Necessary for Productive Replication of Human Papillomavirus 31.Journal of virology · 2015Article
- A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans.PLoS genetics · 2015Article
- Replication intermediates of the linear mitochondrial DNA of Candida parapsilosis suggest a common recombination based mechanism for yeast mitochondria.The Journal of biological chemistry · 2014Article
- Inverted repeats and genome architecture conversions of terrestrial isopods mitochondrial DNA.Journal of molecular evolution · 2013Article
- Mechanism of homologous recombination and implications for aging-related deletions in mitochondrial DNA.Microbiology and molecular biology reviews : MMBR · 2013Review
- ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication.PLoS pathogens · 2013Article
- Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis.BMC biology · 2011Article
- Transfection of plant mitochondria and in organello gene integration.Nucleic acids research · 2011Article
- The replication of plastid minicircles involves rolling circle intermediates.Nucleic acids research · 2009Article
- Survey of extrachromosomal circular DNA derived from plant satellite repeats.BMC plant biology · 2008Article
- Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.Molecular and cellular biology · 2005Article
- Mhr1p-dependent concatemeric mitochondrial DNA formation for generating yeast mitochondrial homoplasmic cells.Molecular biology of the cell · 2004Article
- Mitochondrial genome diversity: evolution of the molecular architecture and replication strategy.Current genetics · 2003Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitochondrial (mt) plasmid mp1 of Chenopodium album replicates by a rolling-circle (RC) mechanism initiated at two double-stranded replication origins (dso1 and dso2). Two-dimensional gel electrophoresis and electron microscopy of early mp1 replication intermediates revealed novel spots. Ribonucleotide (R)-loops were identified at dso1, which function as a precursor for the RCs in vivo and in vitro. Bacteriophage T4-like networks of highly branched mp1 concatemers with up to 20 monomer units were mapped and shown to be mainly formed by replicating, invading, recombining and resolving molecules. A new model is proposed in which concatemers were separated into single units by a "snap-back" mechanism and homologous recombination. dso1 is a recombination hotspot, with sequence homology to bacterial Xer recombination cores. mp1 is a unique eukaryotic plasmid that expresses features of phages like T4 and could serve as a model system for replication and maintenance of DNA concatemers.
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