ArticleThe EMBO journal2002
GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Role of the pioneer transcription factor GATA2 in health and disease.Journal of molecular medicine (Berlin, Germany) · 2023Review
- Article
- GATA2 regulates dendritic cell differentiation.Blood · 2016Article
- Cell cycle regulation of hematopoietic stem or progenitor cells.International journal of hematology · 2016Review
- Vasculogenic and hematopoietic cellular progenitors are scattered within the prenatal mouse heart.Histochemistry and cell biology · 2015Article
- GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.Angiogenesis · 2013Article
- Hematopoietic stem cells: transcriptional regulation, ex vivo expansion and clinical application.Current molecular medicine · 2012Review
- Evidence for the transmission of neoplastic properties from transformed to normal human stem cells.Oncogene · 2011Article
- Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.Nature medicine · 2011Article
- Review
- Article
- Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.Oncogene · 2010Article
- Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate.PLoS computational biology · 2010Article
- Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene.The Journal of biological chemistry · 2008Article
- Notch ligand Delta-1 differentially modulates the effects of gp130 activation on interleukin-6 receptor alpha-positive and -negative human hematopoietic progenitors.Cancer science · 2007Article
- Multipotential differentiation ability of GATA-1-null erythroid-committed cells.Genes & development · 2006Article
- Article
- Developmental relationship between hematopoietic and endothelial cells.Immunologic research · 2005Review
- Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system.Molecular and cellular biology · 2004Article
- GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells.The Journal of experimental medicine · 2004Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GATA-2 is a zinc finger transcription factor essential for the development of hematopoiesis. While GATA-2 is generally considered to play an important role in the biology of hematopoietic stem and progenitor cells, its function within these compartments is not well understood. Here we have employed both conditional expression of GATA-2 and conditional activation of a GATA-2/estrogen receptor (ER) chimera to examine the effect of enforced GATA-2 expression in the development and differentiation of hematopoietic progenitors from murine embryonic stem cells. Consistent with the phenotype of GATA-2 null animals, conditional expression of GATA-2 from a tetracycline-inducible promoter enhanced the production of hematopoietic progenitors. Conditional activation of a GATA-2/ER chimera produced essentially opposite effects to those observed with conditional GATA-2 expression. GATA-2 and GATA-2/ER differ in their binding activities and transcriptional interactions from other hematopoietic-associated transcription factors such as c-Myb and PU.1. While we have exploited these differences in activity to explore the transcriptional networks underlying hematopoietic cell fate determination, our results suggest that care should be taken in interpreting results obtained using only chimeric proteins.
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