ArticleThe EMBO journal2002
Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 208 citations in OpenAlex.
- Gene regulatory complexes: their role and regulation across normal and malignant hematopoiesis.Experimental hematology · 2025Review
- Transcription factors regulating vasculogenesis and angiogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Review
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- Low-Input Whole-Genome Bisulfite Sequencing.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.Cell reports · 2020Article
- A Bayesian data fusion based approach for learning genome-wide transcriptional regulatory networks.BMC bioinformatics · 2020Article
- Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis.Nature cell biology · 2020Article
- Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development.Genome research · 2019Article
- Fli-1 overexpression in erythroleukemic cells promotes erythroid de-differentiation while Spi-1/PU.1 exerts the opposite effect.International journal of oncology · 2017Article
- Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach.Nucleic acids research · 2017Article
- Article
- ConBind: motif-aware cross-species alignment for the identification of functional transcription factor binding sites.Nucleic acids research · 2016Article
- The analysis of novel distal Cebpa enhancers and silencers using a transcriptional model reveals the complex regulatory logic of hematopoietic lineage specification.Developmental biology · 2016Article
- Specification and function of hemogenic endothelium during embryogenesis.Cellular and molecular life sciences : CMLS · 2016Review
- Article
- 3off2: A network reconstruction algorithm based on 2-point and 3-point information statistics.BMC bioinformatics · 2016Article
- The hematopoietic regulator, ELF-1, enhances the transcriptional response to Interferon-β of the OAS1 anti-viral gene.Scientific reports · 2015Article
- Epigenetic program and transcription factor circuitry of dendritic cell development.Nucleic acids research · 2015Article
- A microfluidic device for epigenomic profiling using 100 cells.Nature methods · 2015Article
- Mouse models for core binding factor leukemia.Leukemia · 2015Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Stem cells are a central feature of metazoan biology. Haematopoietic stem cells (HSCs) represent the best-characterized example of this phenomenon, but the molecular mechanisms responsible for their formation remain obscure. The stem cell leukaemia (SCL) gene encodes a basic helix-loop-helix (bHLH) transcription factor with an essential role in specifying HSCs. Here we have addressed the transcriptional hierarchy responsible for HSC formation by characterizing an SCL 3' enhancer that targets expression to HSCs and endothelium and their bipotential precursors, the haemangioblast. We have identified three critical motifs, which are essential for enhancer function and bind GATA-2, Fli-1 and Elf-1 in vivo. Our results suggest that these transcription factors are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.