ArticleDigestive diseases and sciences2002
Expression of G1 phase cyclins in human gastric cancer and gastric mucosa of first-degree relatives.
Article in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Human gene control by vital oncogenes: revisiting a theoretical model and its implications for targeted cancer therapy.International journal of molecular sciences · 2012Review
- Nuclear translocation of β-catenin correlates with CD44 upregulation in Helicobacter pylori-infected gastric carcinoma.Molecular and cellular biochemistry · 2011Article
- Article
- Elevated risk for gastric adenocarcinoma can be predicted from histomorphology.World journal of gastroenterology · 2006Review
- Eradication of H pylori for the prevention of gastric cancer.World journal of gastroenterology · 2006Review
- Activation of beta-catenin by carcinogenic Helicobacter pylori.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the expression of D-type cyclins and cyclin E in gastric cancer patients (N = 34), in healthy first-degree relatives of gastric cancer patients (N = 29), and in control subjects (N = 18). Expression of cyclins D1, D2, D3, and E was determined by RT-PCR. Localization of cyclin expression was determined by immunohistochemistry. Expression of cyclins D2, D3, and E was more frequently detected in tumor tissue compared with tumor-free gastric mucosa (P < 0.05) and was associated with the presence of intestinal metaplasia. In contrast, cyclin D1 was frequently expressed in both tumor- and tumor-free tissue. Cyclin D3 expression was more frequently detected in the antrum mucosa of first-degree relatives compared to controls (P < 0.01) and was associated with the presence of Helicobacter pylori. Our data suggest that deregulation of G1 phase cyclins may play a role in gastric carcinogenesis, and may point to the presence of molecular alterations in individuals at an increased risk for gastric cancer.
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