Evidence map›Paper›PMID 12063236›Full record

ArticleAJNR. American journal of neuroradiology

Iron-induced susceptibility effect at the globus pallidus causes underestimation of flow and volume on dynamic susceptibility contrast-enhanced MR perfusion images.

Kei Yamada, R Gilberto Gonzalez, Leif ØStergaard, Suzanne Komili, Robert M Weisskoff, Bruce R Rosen, Walter J Koroshetz, Tsunehiko Nishimura, A Gregory Sorensen

Registry-linked trialAbstract read
PubMed Full text at PMC
In one paragraph

Article in AJNR. American journal of neuroradiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01836055 (Comparing Lesion Contrast With Both Magnevist and Gadavist and Understanding the Cerebral Perfusion Patterns of Patients With Multiple Sclerosis), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01836055 terminatednot on this map

Comparing Lesion Contrast With Both Magnevist and Gadavist and Understanding the Cerebral Perfusion Patterns of Patients With Multiple Sclerosis (MS) Using Magnetic Resonance Imaging (MRI)

TypeobservationalSponsorWayne State UniversityRan2012 to 2014Enrolled19ConditionsMultiple Sclerosis
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kei YamadaDepartment of Radiology, Kyoto Prefectural University of Medicine, Kyoto City, Japan.
R Gilberto Gonzalez
Leif ØStergaard
Suzanne Komili
Robert M Weisskoff
Bruce R Rosen
Walter J Koroshetz
Tsunehiko Nishimura
A Gregory Sorensen

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
PERFUSION IMAGING WITH MAGNETIC RESONANCER01HL039810 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1988 to 2002
$919k
NCRR NIH HHS P41 RR014075NCRR NIH HHS P41-RR14075NHLBI NIH HHS R01 HL039810NHLBI NIH HHS R01-HL39810NINDS NIH HHS R01NS8477
6 · The paper itself

Abstract

background and purposeAge-related iron accumulation in extrapyramidal nuclei causes T2 shortening, which may result in decreased signal intensity in these areas on MR images. Because the dynamic susceptibility contrast-enhanced technique uses heavily T2*- or T2-weighted images, the iron-induced susceptibility may have direct impact on perfusion imaging. The purpose of this study was to assess the effect of iron-induced susceptibility on the calculated perfusion parameters. The difference of this effect between gradient-echo and spin-echo sequences was also assessed.

methodsDynamic susceptibility contrast-enhanced MR perfusion imaging data of 12 patients were used for this study. Perfusion images were obtained using a single shot spin-echo echo-planar imaging sequence in seven patients and a gradient-echo echo-planar imaging sequence in five patients. Region of interest measurements of relative cerebral blood flow, relative cerebral blood volume, and mean transit time were obtained at various parts of the gray matter, including the globus pallidus, putamen, caudate nucleus, thalamus, and cerebral cortex of temporal, frontal, and occipital lobes. The baseline signal intensity on the source images and the magnitude of signal change (DeltaR2* or DeltaR2) were also assessed.

resultsThe globus pallidus had statistically significantly lower values of relative cerebral blood flow, relative cerebral blood volume, baseline signal intensity, and magnitude of signal change compared with other parts of the gray matter for both gradient-echo and spin-echo sequences (P <.05). Underestimations of these values were more prominent for the gradient-echo than for the spin-echo sequence. Little variance in the measured mean transit time was noted.

conclusionIron-induced susceptibility effect may lead to underestimation of relative cerebral blood flow and relative cerebral blood volume in the basal ganglia.

Indexed as

Blood VolumeCerebrovascular CirculationEcho-Planar ImagingAgedContrast MediaGlobus PallidusHumansIronMiddle AgedContrast MediaIron

Identifiers

PMID12063236
PMCPMC7976913

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.