ArticleProceedings of the National Academy of Sciences of the United States of America2002
A methodological bias toward overestimation of molecular evolutionary time scales.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Article
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- Testing the molecular clock using mechanistic models of fossil preservation and molecular evolution.Proceedings. Biological sciences · 2017Article
- The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle.Genetics · 2013Article
- Origin and evolution of dishevelled.G3 (Bethesda, Md.) · 2013Article
- A total-evidence approach to dating with fossils, applied to the early radiation of the hymenoptera.Systematic biology · 2012Article
- The origin of modern frogs (Neobatrachia) was accompanied by acceleration in mitochondrial and nuclear substitution rates.BMC genomics · 2012Article
- Phylogenomic datasets provide both precision and accuracy in estimating the timescale of placental mammal phylogeny.Proceedings. Biological sciences · 2012Article
- The impact of the geologic history and paleoclimate on the diversification of East african cichlids.International journal of evolutionary biology · 2012Article
- Major radiations in the evolution of Caviid rodents: reconciling fossils, ghost lineages, and relaxed molecular clocks.PloS one · 2012Article
- Is speciation accompanied by rapid evolution? Insights from comparing reproductive and nonreproductive transcriptomes in Drosophila.International journal of evolutionary biology · 2011Article
- The complete mitochondrial genomes of the whistling duck (Dendrocygna javanica) and black swan (Cygnus atratus): dating evolutionary divergence in Galloanserae.Molecular biology reports · 2010Article
- Molecular systematics: A synthesis of the common methods and the state of knowledge.Cellular & molecular biology letters · 2010Review
- How to summarize estimates of ancestral divergence times.Evolutionary bioinformatics online · 2008Article
- Higher-order phylogeny of modern birds (Theropoda, Aves: Neornithes) based on comparative anatomy. II. Analysis and discussion.Zoological journal of the Linnean Society · 2007Article
- Rates and patterns of gene duplication and loss in the human genome.Proceedings. Biological sciences · 2005Article
- Genomic data support the hominoid slowdown and an Early Oligocene estimate for the hominoid-cercopithecoid divergence.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The timing of eukaryotic evolution: does a relaxed molecular clock reconcile proteins and fossils?Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Estimating metazoan divergence times with a molecular clock.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- A molecular timescale of eukaryote evolution and the rise of complex multicellular life.BMC evolutionary biology · 2004Article
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3 authors.
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Abstract
There is presently a conflict between fossil- and molecular-based evolutionary time scales. Molecular approaches for dating the branches of the tree of life frequently lead to substantially deeper times of divergence than those inferred by paleontologists. The discrepancy between molecular and fossil estimates persists despite the booming growth of sequence data sets, which increasingly feeds the interpretation that molecular estimates are older than stratigraphic dates because of deficiencies in the fossil record. Here we show that molecular time estimates suffer from a methodological handicap, namely that they are asymmetrically bounded random variables, constrained by a nonelastic boundary at the lower end, but not at the higher end of the distribution. This introduces a bias toward an overestimation of time since divergence, which becomes greater as the length of the molecular sequence and the rate of evolution decrease.
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