ArticleNucleic acids research2002
Properties of triple helices formed by parallel-stranded hairpins containing 8-aminopurines.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Conformation and protein interactions of intramolecular DNA and phosphorothioate four-way junctions.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Triplex Hybridization-Based Nanosystem for the Rapid Screening of Pneumocystis Pneumonia in Clinical Samples.Journal of fungi (Basel, Switzerland) · 2020Article
- LNA units present in [RSC advances · 2020Article
- Synthesis and surface characterization of new triplex polymer of Ag(I) and mixture nucleosides: cytidine and 8-bromoguanosine.Heliyon · 2019Article
- Alternative DNA structure formation in the mutagenic human c-MYC promoter.Nucleic acids research · 2017Article
- Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells.BMC immunology · 2016Article
- Targeting duplex DNA with chimeric α,β-triplex-forming oligonucleotides.Nucleic acids research · 2012Article
- Sensitive and label-free biosensing of RNA with predicted secondary structures by a triplex affinity capture method.Nucleic acids research · 2012Article
- Structural properties of g,t-parallel duplexes.Journal of nucleic acids · 2010Article
- Polypurine hairpins directed against the template strand of DNA knock down the expression of mammalian genes.The Journal of biological chemistry · 2009Article
- Monitoring denaturation behaviour and comparative stability of DNA triple helices using oligonucleotide-gold nanoparticle conjugates.Nucleic acids research · 2004Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parallel-stranded hairpins with a polypyrimidine sequence linked to a complementary purine carrying 8-aminopurines such as 8-aminoadenine, 8-aminoguanine and 8-aminohypoxanthine bind polypyrimidine sequences complementary (in an antiparallel sense) to the purine part by a triple helix. The relative stabilities of triplexes were assessed by UV-absorption melting experiments as a function of pH and salt concentration. Hairpins carrying 8-aminopurines give very stable triple helical structures even at neutral pH, as confirmed by gel-shift experiments, circular dichroism and nuclear magnetic resonance spectroscopy. The modified hairpins may be redesigned to cope with small interruptions in the polypyrimidine target sequence.
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