ArticleGenes and immunity2002
Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Improving reproducibility and translational potential of mouse models: lessons from studying leishmaniasis.Frontiers in immunology · 2025Review
- Novel Loci Controlling Parasite Load in Organs of Mice Infected WithFrontiers in immunology · 2019Article
- Mouse Chromosome 4 Is Associated with the Baseline and Allergic IgE Phenotypes.G3 (Bethesda, Md.) · 2017Article
- Gene-specific sex effects on eosinophil infiltration in leishmaniasis.Biology of sex differences · 2016Article
- Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system.Journal of neuroinflammation · 2013Article
- Mapping the genes for susceptibility and response to Leishmania tropica in mouse.PLoS neglected tropical diseases · 2013Article
- Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9.Infection and immunity · 2012Article
- Genetic control of canine leishmaniasis: genome-wide association study and genomic selection analysis.PloS one · 2012Article
- Genetic control of resistance to Trypanosoma brucei brucei infection in mice.PLoS neglected tropical diseases · 2011Article
- Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection.Immunogenetics · 2009Article
- Identification of a major susceptibility locus for lethal graft-versus-host disease in MHC-matched mice.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Comparative genomics of Toll-like receptor signalling in five species.BMC genomics · 2009Article
- Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12.Immunogenetics · 2009Article
- Mouse genetic model for antigen-induced airway manifestations of asthma.Genes and immunity · 2007Article
- Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects.Genes and immunity · 2006Article
- Genetic control of Bordetella pertussis infection: identification of susceptibility loci using recombinant congenic strains of mice.Infection and immunity · 2005Article
- Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice.Infection and immunity · 2003Article
- Looking back and looking forward.Genes and immunity · 2003Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The strain BALB/cHeA (BALB/c) is a high producer, and STS/A (STS) a low producer of IgE after Leishmania major infection. We analyzed this strain difference using 20 recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% of genes of the strain STS on the BALB/c background. Strains CcS-16 and -20 exhibit a high and a low IgE level, respectively. In their F(2) hybrids with BALB/c we mapped nine Leishmania major response (Lmr) loci. Two of them we previously found to influence IgE level in CcS-5. IgE production in CcS-16 is controlled by loci on chromosomes 2, 10, 16 and 18 and in CcS-20 by loci on chromosomes 1, 3, 4, 5 and 8. The STS alleles of loci on chromosomes 1, 4, 5, 8 and 10 were associated with a low, whereas the STS alleles on chromosomes 16 and 18 with a high IgE production. The loci on chromosomes 2 and 3 have no apparent individual effect, but interact with the loci on chromosomes 10 and 1, respectively. The loci on chromosomes 10 and 18 were mapped in the regions homologous with the human regions containing genes that control total serum IgE and intensity of infection by Schistosoma mansoni, suggesting that some Lmr loci may participate in the pathways influencing atopic reactions and responses to several parasites. The definition of genes controlling anti-parasite responses will permit a better understanding of pathways and genetic diversity underlying the disease phenotypes.
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Registered trials
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