ArticleMolecular biology of the cell2002
Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- R-loop resolution by ARIP4 helicase promotes androgen-mediated transcription induction.Science advances · 2024Article
- The TRAF3-DYRK1A-RAD54L2 complex maintains ACE2 expression to promote SARS-CoV-2 infection.Journal of virology · 2024Article
- RAD54L2 counters TOP2-DNA adducts to promote genome stability.Science advances · 2023Article
- RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons.Science advances · 2023Article
- Estrogen associates with female predominance in Xp11.2 translocation renal cell carcinoma.Scientific reports · 2023Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population.BMC cancer · 2022Article
- Article
- Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer.Oncotarget · 2015Article
- Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation.Scientific reports · 2015Article
- A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.Nucleic acids research · 2013Article
- Nuclear receptor coactivators: structural and functional biochemistry.Biochemistry · 2011Review
- Regulation of androgen-responsive transcription by the chromatin remodeling factor CHD8.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1.Molecular biology of the cell · 2009Article
- NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Biochemical characterization of androgen receptor-interacting protein 4.The Biochemical journal · 2006Article
- Identification of multiple distinct Snf2 subfamilies with conserved structural motifs.Nucleic acids research · 2006Article
- BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI/SNF.Molecular and cellular biology · 2005Article
- Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4.Molecular and cellular biology · 2004Article
- A model for dsDNA translocation revealed by a structural motif common to RecG and Mfd proteins.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear receptors, including the androgen receptor (AR), regulate target cell transcription through interaction with auxiliary proteins to modify chromatin structure. We describe herein a novel AR-interacting protein, termed ARIP4, that has structural features typical of the SNF2-like protein family. With regard to the Snf2 domain, the closest homolog of ARIP4 is the ATRX protein. ARIP4 is a nuclear protein and comprises 1466 amino acids. It interacts with AR in vitro and in cultured yeast and mammalian cells. ARIP4 can be labeled with 8-azido-[gamma-32P]ATP and exhibits DNA-dependent ATPase activity. Like several ATP-dependent chromatin remodeling proteins, ARIP4 generates superhelical torsion within linear DNA fragments in an ATP-dependent manner. With a stably integrated target promoter, ARIP4 elicits a modest enhancement of AR-dependent transactivation. In transient cotransfection assays, ARIP4 modulates AR function in a promoter-dependent manner; it enhances receptor activity on minimal promoters, but does not activate more complex promoters. ARIP4 mutants devoid of ATPase activity fail to alter DNA topology and behave as trans-dominant negative regulators of AR function in transient assays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.