ArticleMolecular biology of the cell2002
Null mutation of AtCUL1 causes arrest in early embryogenesis in Arabidopsis.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 161 citations in OpenAlex.
- Ubiquitination of OsCSN5 by OsPUB45 activates immunity by modulating the OsCUL3a-OsNPR1 module.Science advances · 2025Article
- Analyses of Cullin1 homologs reveal functional redundancy in S-RNase-based self-incompatibility and evolutionary relationships in eudicots.The Plant cell · 2023Article
- Mendel: From genes to genome.Plant physiology · 2022Article
- Negative regulation of seed germination by maternal AFB1 and AFB5 in Arabidopsis.Bioscience reports · 2022Article
- The Arabidopsis F-box protein FBW2 targets AGO1 for degradation to prevent spurious loading of illegitimate small RNA.Cell reports · 2022Article
- DEAD-BOX RNA HELICASE 27 regulates microRNA biogenesis, zygote division, and stem cell homeostasis.The Plant cell · 2021Article
- Effect of Paternal Genome Excess on the Developmental and Gene Expression Profiles of Polyspermic Zygotes in Rice.Plants (Basel, Switzerland) · 2021Article
- HOS15 is a transcriptional corepressor of NPR1-mediated gene activation of plant immunity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Molecular variation in a functionally divergent homolog of FCA regulates flowering time in Arabidopsis thaliana.Nature communications · 2020Article
- Conservation of centromeric histone 3 interaction partners in plants.Journal of experimental botany · 2020Article
- A Suppressor Screen for AGO1 Degradation by the Viral F-Box P0 Protein Uncovers a Role for AGO DUF1785 in sRNA Duplex Unwinding.The Plant cell · 2018Article
- Characterization and comparative expression analysis of CUL1 genes in rice.Genes & genomics · 2018Article
- Mass Spectrometric Analyses Reveal a Central Role for Ubiquitylation in Remodeling the Arabidopsis Proteome during Photomorphogenesis.Molecular plant · 2017Article
- Dissection of a major QTL qhir1 conferring maternal haploid induction ability in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Analysis of CFB, a cytokinin-responsive gene of Arabidopsis thaliana encoding a novel F-box protein regulating sterol biosynthesis.Journal of experimental botany · 2017Article
- Re-analysis of protein data reveals the germination pathway and up accumulation mechanism of cell wall hydrolases during the radicle protrusion step of seed germination in Podophyllum hexandrum- a high altitude plant.Frontiers in plant science · 2015Article
- A new temperature-insensitive allele of the Arabidopsis AXR6/CUL1 locus derived from a missense mutation in the C-terminal RBX1 binding region.Plant signaling & behavior · 2015Article
- A tobacco homolog of DCN1 is involved in pollen development and embryogenesis.Plant cell reports · 2014Article
- Article
- Dynamic regulation and function of histone monoubiquitination in plants.Frontiers in plant science · 2014Review
8 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
The SCF (for SKP1, Cullin/CDC53, F-box protein) ubiquitin ligase targets a number of cell cycle regulators, transcription factors, and other proteins for degradation in yeast and mammalian cells. Recent genetic studies demonstrate that plant F-box proteins are involved in auxin responses, jasmonate signaling, flower morphogenesis, photocontrol of circadian clocks, and leaf senescence, implying a large spectrum of functions for the SCF pathway in plant development. Here, we present a molecular and functional characterization of plant cullins. The Arabidopsis genome contains 11 cullin-related genes. Complementation assays revealed that AtCUL1 but not AtCUL4 can functionally complement the yeast cdc53 mutant. Arabidopsis mutants containing transfer DNA (T-DNA) insertions in the AtCUL1 gene were shown to display an arrest in early embryogenesis. Consistently, both the transcript and the protein of the AtCUL1 gene were found to accumulate in embryos. The AtCUL1 protein localized mainly in the nucleus but also weakly in the cytoplasm during interphase and colocalized with the mitotic spindle in metaphase. Our results demonstrate a critical role for the SCF ubiquitin ligase in Arabidopsis embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.