ArticleJournal of bacteriology2002
Activation of prophage eib genes for immunoglobulin-binding proteins by genes from the IbrAB genetic island of Escherichia coli ECOR-9.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
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- Classification of a HypervirulentFrontiers in microbiology · 2016Article
- Identification of a phage-encoded Ig-binding protein from invasive Neisseria meningitidis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA.Nucleic acids research · 2013Article
- The CgrA and CgrC proteins form a complex that positively regulates cupA fimbrial gene expression in Pseudomonas aeruginosa.Journal of bacteriology · 2011Article
- Distribution and phylogeny of immunoglobulin-binding protein G in Shiga toxin-producing Escherichia coli and its association with adherence phenotypes.Infection and immunity · 2010Article
- Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility.Journal of bacteriology · 2008Article
- Local and global regulators linking anaerobiosis to cupA fimbrial gene expression in Pseudomonas aeruginosa.Journal of bacteriology · 2007Article
- Identification of Escherichia coli O157:H7 genomic regions conserved in strains with a genotype associated with human infection.Applied and environmental microbiology · 2007Article
- In vivo gene expression analysis identifies genes required for enhanced colonization of the mouse urinary tract by uropathogenic Escherichia coli strain CFT073 dsdA.Infection and immunity · 2007Article
- A new immunoglobulin-binding protein, EibG, is responsible for the chain-like adhesion phenotype of locus of enterocyte effacement-negative, shiga toxin-producing Escherichia coli.Infection and immunity · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Four distinct Escherichia coli immunoglobulin-binding (eib) genes, each of which encodes a surface-exposed protein that binds immunoglobulins in a nonimmune manner, are carried by separate prophages in E. coli reference (ECOR) strain ECOR-9. Each eib gene was transferred to test E. coli strains, both in the form of multicopy recombinant plasmids and as lysogenized prophage. The derived lysogens express little or no Eib protein, in sharp contrast to the parental lysogen, suggesting that ECOR-9 has an expression-enhancing activity that the derived lysogens lack. Supporting this hypothesis, we cloned from ECOR-9 overlapping genes, ibrA and ibrB (designation is derived from "immunoglobulin-binding regulator"), which together activated eib expression in the derived lysogens. The proteins encoded by ibrA and ibrB are very similar to uncharacterized proteins encoded by genes of Salmonella enterica serovar Typhi and E. coli O157:H7 (in a prophage-like element of the Sakai strain and in two O islands of strain EDL933). The genomic segment containing ibrA and ibrB has been designated the IbrAB island. It contains regions of homology to the Shiga toxin-converting prophage, Stx2, as well as genes homologous to phage antirepressor genes. The left boundary between the IbrAB island and the chromosomal framework is located near min 35.8 of the E. coli K-12 genome. Homology to IbrAB was found in certain other ECOR strains, including the other five eib-positive strains and most strains of the phylogenetic group B2. Sequencing of a 1.1-kb portion of ibrAB revealed that the other eib-positive strains diverge by </=0.1% from ECOR-9, whereas eib-negative ECOR-47 diverges by 16%.
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