ArticleJournal of bacteriology2002
Type 1 capsule genes of Staphylococcus aureus are carried in a staphylococcal cassette chromosome genetic element.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 98 citations in OpenAlex.
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- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing.Frontiers in cellular and infection microbiology · 2023Review
- Genome Sequencing of a Historic Staphylococcus aureus Collection Reveals New Enterotoxin Genes and Sheds Light on the Evolution and Genomic Organization of This Key Virulence Gene Family.Journal of bacteriology · 2021Article
- Improved diagnostic prediction of the pathogenicity of bloodstream isolates of Staphylococcus epidermidis.PloS one · 2021Article
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- Staphylococcal Plasmids, Transposable and Integrative Elements.Microbiology spectrum · 2018Review
- Factors Contributing to the Evolution ofFrontiers in microbiology · 2018Review
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- Staphylococcus aureus mobile genetic elements.Molecular biology reports · 2014Review
- Isolation and characterization of Staphylococcus aureus strains from a Paso del Norte dairy.Journal of dairy science · 2013Article
- Genomic Basis for Methicillin Resistance in Staphylococcus aureus.Infection & chemotherapy · 2013Review
- DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands.Antimicrobial agents and chemotherapy · 2012Article
- High-frequency transposition for determining antibacterial mode of action.Nature chemical biology · 2011Article
- High proportion of wrongly identified methicillin-resistant Staphylococcus aureus carriers by use of a rapid commercial PCR assay due to presence of staphylococcal cassette chromosome element lacking the mecA gene.Journal of clinical microbiology · 2011Article
- Mobile genetic elements of Staphylococcus aureus.Cellular and molecular life sciences : CMLS · 2010Review
- Characterization of the structure and biological functions of a capsular polysaccharide produced by Staphylococcus saprophyticus.Journal of bacteriology · 2010Article
- Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.Antimicrobial agents and chemotherapy · 2010Article
- Multiplex real-time PCR for rapid Staphylococcal cassette chromosome mec typing.Journal of clinical microbiology · 2009Article
- Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.Antimicrobial agents and chemotherapy · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cap1 genes are required for the synthesis of type 1 capsular polysaccharide (CP1) in Staphylococcus aureus. We previously showed that the cap1 locus was associated with a discrete genetic element in S. aureus M. In this report, we defined the boundaries of the cap1 element by comparing its restriction pattern to that of a corresponding region from the CP1-negative strain Becker. The element was located in the SmaI-G chromosomal fragment of the standard mapping strain NCTC8325. The sequences of the entire cap1 element and the flanking regions were determined. We found that there were two additional cap1 genes not previously identified. The cap1 operon was located in a staphylococcal cassette chromosome (SCC) element similar to the resistance island SCCmec recently described for methicillin resistance in S. aureus. Notably, the SCCcap1 element was located at the same insertion site as all the SCCmec elements in the staphylococcal chromosome. The excision of SCCcap1 could be demonstrated only in the presence of the recombinase genes from an SCCmec element, verifying that SCCcap1 is a genuine SCC element but defective in mobilization. A novel enterotoxin gene, whose transcript was detected by Northern blotting, was found next to the SCCcap1 locus. We propose that the enterotoxin gene and SCCcap1 were inserted into this locus at the juxtaposition by independent events. Sequence comparison revealed numerous DNA rearrangements and mutations in SCCcap1 and the left flanking region, suggesting that the SCCcap1 had been inserted at the SCC attC site a long time ago. In addition, most genes in this region were incomplete, with the exception of the 15 cap1 genes, implying that the cap1 genes confer a survival advantage on strain M.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.