ArticleJournal of bacteriology2002
An adenylyl cyclase, CyaA, of Myxococcus xanthus functions in signal transduction during osmotic stress.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Genome analysis of a plasmid-bearing myxobacterimFrontiers in microbiology · 2023Article
- Myxobacterial Genomics and Post-Genomics: A Review of Genome Biology, Genome Sequences and Related 'Omics Studies.Microorganisms · 2021Review
- An ambruticin-sensing complex modulates Myxococcus xanthus development and mediates myxobacterial interspecies communication.Nature communications · 2020Article
- Second messengers and divergent HD-GYP phosphodiesterases regulate 3',3'-cGAMP signaling.Molecular microbiology · 2020Article
- Biochemical and functional characterization of SpdA, a 2', 3'cyclic nucleotide phosphodiesterase from Sinorhizobium meliloti.BMC microbiology · 2013Article
- Enzymatic and functional analysis of a protein phosphatase, Pph3, from Myxococcus xanthus.Journal of bacteriology · 2011Article
- Enzymatic and mutational analyses of a class II 3',5'-cyclic nucleotide phosphodiesterase, PdeE, from Myxococcus xanthus.Journal of bacteriology · 2011Article
- Glycine betaine biosynthesized from glycine provides an osmolyte for cell growth and spore germination during osmotic stress in Myxococcus xanthus.Journal of bacteriology · 2010Article
- The prokaryotic origin and evolution of eukaryotic chemosignaling systems.Neuroscience and behavioral physiology · 2009Review
- Involvement of a membrane-bound class III adenylate cyclase in regulation of anaerobic respiration in Shewanella oneidensis MR-1.Journal of bacteriology · 2009Article
- Significant role for ladC in initiation of Legionella pneumophila infection.Infection and immunity · 2008Article
- Cohesion-defective mutants of Myxococcus xanthus.Journal of bacteriology · 2006Article
- Contribution of the cyclic nucleotide phosphodiesterases PdeA and PdeB to adaptation of Myxococcus xanthus cells to osmotic or high-temperature stress.Journal of bacteriology · 2006Article
- An adenylyl cyclase, CyaB, acts as an osmosensor in Myxococcus xanthus.Journal of bacteriology · 2005Article
- Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c.The EMBO journal · 2005Article
- Bacterial signal transduction network in a genomic perspective.Environmental microbiology · 2004Review
- Common extracellular sensory domains in transmembrane receptors for diverse signal transduction pathways in bacteria and archaea.Journal of bacteriology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An adenylyl cyclase gene (cyaA) present upstream of an osmosensor protein gene (mokA) was isolated from Myxococcus xanthus. cyaA encoded a polypeptide of 843 amino acids with a predicted molecular mass of 91,187 Da. The predicted cyaA gene product had structural similarity to the receptor-type adenylyl cyclases that are composed of an amino-terminal sensor domain and a carboxy-terminal catalytic domain of adenylyl cyclase. In reverse transcriptase PCR experiments, the transcript of the cyaA gene was detected mainly during development and spore germination. A cyaA mutant, generated by gene disruption, showed normal growth, development, and germination. However, a cyaA mutant placed under conditions of ionic (NaCl) or nonionic (sucrose) osmostress exhibited a marked reduction in spore formation and spore germination. When wild-type and cyaA mutant cells at developmental stages were stimulated with 0.2 M NaCl or sucrose, the mutant cells increased cyclic AMP accumulation at levels similar to those of the wild-type cells. In contrast, the mutant cells during spore germination had mainly lost the ability to respond to high-ionic osmolarity. In vegetative cells, the cyaA mutant responded normally to osmotic stress. These results suggested that M. xanthus CyaA functions mainly as an ionic osmosensor during spore germination and that CyaA is also required for osmotic tolerance in fruiting formation and sporulation.
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