ArticleThe American journal of pathology2002
Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 148 citations in OpenAlex.
- Multifocal Fibrosing Thyroiditis: an Under-recognized Mimicker of Papillary Thyroid Carcinoma.Endocrine pathology · 2022Review
- The promising role and prognostic value of miR-198 in human diseases.American journal of translational research · 2022Article
- Precursor and borderline lesions of the thyroid (indolent lesions of epithelial origin): from theory to practice.Gland surgery · 2020Review
- Intratumoral Genetic Heterogeneity in Papillary Thyroid Cancer: Occurrence and Clinical Significance.Cancers · 2020Review
- Plasma miR-323 as a Biomarker for Screening Papillary Thyroid Cancer From Healthy Controls.Frontiers in medicine · 2020Article
- Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates.Gland surgery · 2019Article
- Serum miR-22 may be a biomarker for papillary thyroid cancer.Oncology letters · 2019Article
- Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma.Oncotarget · 2016Article
- An Appraisal of Proliferation and Apoptotic Markers in Papillary Thyroid Carcinoma: An Automated Analysis.PloS one · 2016Article
- Cyclin D1 in well differentiated thyroid tumour of uncertain malignant potential.Diagnostic pathology · 2015Article
- Interleukins as markers of inflammation in malignant and benign thyroid disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Interleukin 22 polymorphisms and papillary thyroid cancer.Journal of endocrinological investigation · 2013Observational
- Metastases of renal cell carcinoma to the thyroid gland with synchronous benign and malignant follicular cell-derived neoplasms.Case reports in oncological medicine · 2013Article
- The impact of benign gene expression classifier test results on the endocrinologist-patient decision to operate on patients with thyroid nodules with indeterminate fine-needle aspiration cytopathology.Thyroid : official journal of the American Thyroid Association · 2012Article
- Detection of PAX8/PPARG and RET/PTC rearrangements is feasible in routine air-dried fine needle aspiration smears.Thyroid : official journal of the American Thyroid Association · 2012Article
- Inflammation in thyroid oncogenesis.American journal of cancer research · 2012Article
- Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma.Frontiers in endocrinology · 2012Article
- Follicular-patterned tumors of the thyroid: the battle of benign vs. malignant vs. so-called uncertain.Endocrine pathology · 2011Review
- Article
- Cytological detection of papillary thyroid carcinomas by nuclear membrane decoration with emerin staining.Virchows Archiv : an international journal of pathology · 2010Article
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noninvasive thyroid nodules that exhibit borderline morphological signs of papillary cancer are difficult to diagnose and we do not know if they represent papillary carcinoma precursor lesions. Forty-six such nodules were analyzed for RET activation by immunohistochemistry and, in selected cases, by reverse transcriptase-polymerase chain reaction performed on RNA extracted after laser capture microdissection (LCM) of the tumor foci with and without papillary carcinoma features and positive RET immunoreactivity. RET immunoreactivity was identified, at least focally, in 30 of 46 (65.2%) of the nodules where it closely paralleled the morphological changes. Enough RNA was obtained after LCM in seven samples. RET/PTC1 or RET/PTC3 were detected in microscopic foci with papillary carcinoma features in most of the thyroid nodules (five of seven cases). No RET/PTC1 or RET/PTC3 rearrangements were detected in areas of the same tumors that lacked the cytological alterations. Analysis of clonality in the same nodules selected for LCM demonstrated that two were monoclonal and six were polyclonal. We conclude that RET activation closely parallels the morphological changes, that it is restricted to those areas of the tumor with the cytological alterations and that it is detectable in both mono- and polyclonal tumors. Although the finding of microscopic foci indicative of papillary carcinoma in a hyperplastic or adenomatous nodule does not justify the interpretation of the entire lesion as papillary carcinoma, it is possible that such foci may precede the development of invasive papillary cancer.
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