ArticleThe American journal of pathology2002
Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Transcriptomics of Wet Skin Biopsies Predict Early Radiation-Induced Hematological Damage in a Mouse Model.Genes · 2022Article
- How cell migration helps immune sentinels.Frontiers in cell and developmental biology · 2022Review
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- Schmid's Type of Metaphyseal Chondrodysplasia: Diagnosis and Management.Orthopaedic surgery · 2018Article
- Novel insights into the function and dynamics of extracellular matrix in liver fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Article
- The humerus of Eusthenopteron: a puzzling organization presaging the establishment of tetrapod limb bone marrow.Proceedings. Biological sciences · 2014Article
- Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and laminin.Stem cells (Dayton, Ohio) · 2014Article
- How to build an inducible cartilage-specific transgenic mouse.Arthritis research & therapy · 2014Review
- Defective endochondral ossification-derived matrix and bone cells alter the lymphopoietic niche in collagen X mouse models.Stem cells and development · 2013Article
- Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model.Arthritis and rheumatism · 2012Article
- Growth-plate cartilage in chronic renal failure.Pediatric nephrology (Berlin, Germany) · 2010Review
- Congenic mice confirm that collagen X is required for proper hematopoietic development.PloS one · 2010Article
- Bone growth during rapamycin therapy in young rats.BMC pediatrics · 2009Article
- Heparan sulfate proteoglycans: a GAGgle of skeletal-hematopoietic regulators.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Review
- Altered endochondral ossification in collagen X mouse models leads to impaired immune responses.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Chicken collagen X regulatory sequences restrict transgene expression to hypertrophic cartilage in mice.The American journal of pathology · 2004Article
- Partial characterization of cell-type X collagen interactions.The Biochemical journal · 2003Article
- Col11a1 Regulates Bone Microarchitecture during Embryonic Development.Journal of developmental biologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Each skeletal element where marrow develops is first defined by a hypertrophic cartilage blueprint. Through programmed tissue substitution, the cartilaginous skeletal model is replaced by trabecular bone and marrow, with accompanying longitudinal tissue growth. During this process of endochondral ossification, hypertrophic cartilage expresses a unique matrix molecule, collagen X. Previously we reported that transgenic mice with dominant interference collagen X mutations develop variable skeleto-hematopoietic abnormalities, manifested as growth plate compressions, diminished trabecular bone, and reduced lymphatic organs (Nature 1993, 365:56). Here, histology and flow cytometry reveal marrow hypoplasia and impaired hematopoiesis in all collagen X transgenic mice. A subset of mice with perinatal lethality manifested the most severe skeletal defects and a reduction of marrow hematopoiesis, highlighted by a lymphocyte decrease. Thymic reduction is accompanied by a paucity of cortical immature T cells, consistent with the marrow's inability to replenish maturing cortical lymphocytes. Diminished spleens exhibit indistinct lymphatic nodules and red pulp depletion; the latter correlates with erythrocyte-filled vascular sinusoids in marrows. All mice display reduced B cells in marrows and spleens, and elevated splenic T cells. These hematopoietic defects underscore an unforeseen link between hypertrophic cartilage, endochondral ossification, and establishment of the marrow microenvironment required for blood cell differentiation.
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