ArticleThe American journal of pathology2002
An invasion-independent pathway of blood-borne metastasis: a new murine mammary tumor model.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Vessels encapsulating tumor clusters in hepatocellular carcinoma: a distinct metastatic pathway with diagnostic and therapeutic significance.Journal of translational medicine · 2026Review
- Venous vasculature drives neovascularization and stroma formation in pancreatic neuroendocrine tumors via intussusceptive angiogenesis and vein intravasation.Histology and histopathology · 2025Article
- Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature.Discover oncology · 2024Review
- Vessels encapsulating tumor clusters: a novel efficacy predictor of hepatic arterial infusion chemotherapy in unresectable hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2023Article
- EMID1, a multifunctional molecule identified in a murine model for the invasion independent metastasis pathway.Scientific reports · 2021Article
- Interstitial Hypertension Suppresses Escape of Human Breast Tumor CellsCellular and molecular bioengineering · 2021Article
- Neutrophil Elastase Facilitates Tumor Cell Intravasation and Early Metastatic Events.iScience · 2020Article
- In vitro vascularized tumor platform for modeling tumor-vasculature interactions of inflammatory breast cancer.Biotechnology and bioengineering · 2020Article
- A Atractylodes lancea polysaccharide inhibits metastasis of human osteosarcoma U-2 OS cells by blocking sialyl Lewis X (sLeJournal of cellular and molecular medicine · 2020Article
- Vessels encapsulating tumor clusters in hepatocellular carcinoma: a unique and valuable pathological imaging.Hepatobiliary surgery and nutrition · 2020Article
- The contribution of platelets to intravascular arrest, extravasation, and outgrowth of disseminated tumor cells.Clinical & experimental metastasis · 2020Review
- Identification of S100A14 as a metastasis-promoting molecule in a murine organotropic metastasis model.Clinical & experimental metastasis · 2019Article
- Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit.Medical sciences (Basel, Switzerland) · 2018Review
- Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer.Translational lung cancer research · 2017Review
- Circulating tumor cell clusters: What we know and what we expect (Review).International journal of oncology · 2016Review
- Tumor cell intravasation.American journal of physiology. Cell physiology · 2016Review
- MicroRNAs and Osteolytic Bone Metastasis: The Roles of MicroRNAs in Tumor-Induced Osteoclast Differentiation.Journal of clinical medicine · 2015Review
- Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion.BMC cancer · 2015Article
- Neoadjuvant sorafenib treatment of clear cell renal cell carcinoma and release of circulating tumor fragments.Neoplasia (New York, N.Y.) · 2014Article
- Molecular analysis of circulating tumour cells-biology and biomarkers.Nature reviews. Clinical oncology · 2014Review
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
It is generally believed that active invasion by cancer cells is essential to the metastatic process. In this report, we describe a murine mammary tumor (MCH66) model of metastasis that does not require invasion into the vascular wall of both the primary tumor and the target organ, in this case, the lung. The process involves intravasation of tumor nests surrounded by sinusoidal blood vessels, followed by intravascular tumor growth in the lung, without penetration of the vascular wall during the process. Comparative studies using a nonmetastatic MCH66 clone (MCH66C8) and another highly invasive metastatic cell line (MCH416) suggested that high angiogenic activity and sinusoidal remodeling of tumor blood vessels were prerequisites for MCH66 metastasis. Differential cDNA analysis identified several genes that were overexpressed by MCH66, including genes for the angiogenesis factor pleiotrophin, and extracellular matrix-associated molecules that may modulate the microenvironment toward neovascularization. Our analyses suggest that tumor angiogenesis plays a role in the induction of invasion-independent metastasis. This model should prove useful in screening and development of new therapeutic agents for cancer metastasis.
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