ArticleInternational journal of legal medicine2002
Immunohistochemical detection of chemokines in human skin wounds and its application to wound age determination.
Article in International journal of legal medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- State-of-the-Art on Wound Vitality Evaluation: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Forensic Impact of the Omics Science Involved in the Wound: A Systematic Review.Frontiers in medicine · 2021Pooled it
- Histological and Immunohistochemical Biomarkers for Wound Age Estimation in Human Skin: A Systematic Review.Cureus · 2026Review
- Immunohistochemical analysis of PDGFR-α for wound age determination.International journal of legal medicine · 2024Article
- Dating Skin Lesions of Forensic Interest by Immunohistochemistry and Immunofluorescence Techniques: A Scoping Literature Review.Diagnostics (Basel, Switzerland) · 2024Article
- Detection of multiple biomarkers associated with satellite cell fate in the contused skeletal muscle of rats for wound age estimation.International journal of legal medicine · 2023Article
- A simplified method for monitoring cytokines in wound fluid.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2023Article
- Macrophage polarity and wound age determination.Scientific reports · 2022Article
- Bone Marrow-Derived Cells and Wound Age Estimation.Frontiers in medicine · 2022Review
- Forensic Application of Epidermal Ubiquitin Expression to Determination of Wound Vitality in Human Compressed Neck Skin.Frontiers in medicine · 2022Article
- Cytokines as new biomarkers of skin wound vitality.International journal of legal medicine · 2021Article
- Mini Review: Forensic Value of Aquaporines.Frontiers in medicine · 2021Review
- Forensic application of epidermal AQP3 expression to determination of wound vitality in human compressed neck skin.International journal of legal medicine · 2018Article
- Immunohistochemical analysis on aquaporin-1 and aquaporin-3 in skin wounds from the aspects of wound age determination.International journal of legal medicine · 2018Article
- Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages.Journal of inflammation (London, England) · 2018Article
- Temporal expression of chitinase-like 3 in wounded murine skin.International journal of legal medicine · 2017Article
- Detection of satellite cells during skeletal muscle wound healing in rats: time-dependent expressions of Pax7 and MyoD in relation to wound age.International journal of legal medicine · 2016Article
- Bruises: is it a case of "the more we know, the less we understand?".Forensic science, medicine, and pathology · 2015Article
- Immunohistochemical analysis on MMP-2 and MMP-9 for wound age determination.International journal of legal medicine · 2015Article
- Detection of endothelial progenitor cells in human skin wounds and its application for wound age determination.International journal of legal medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunohistochemical studies on the time-dependent expression of the chemokines such as interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha were performed on 50 human skin wounds with different wound ages (group I 0-12 h, group II 1-4 days, group III 7-14 days and group IV 17-21 days). In the wound specimens with wound ages between 4 and 12 h, neutrophils mainly showed positive reactions for IL-8, MCP-1 and MIP-1alpha. With increasing wound ages, macrophages and fibroblasts were positively stained with anti-IL-8, MIP-1alpha and MCP-1 antibodies. Morphometrically, there was a similar distribution in the positive ratios of the inflammatory cells among IL-8, MCP-1 and MIP-alpha. The positive ratios of each chemokine were very low in group I and a considerable increase of the positive ratios in each chemokine was observed in group II (mean +/- standard error IL-8: 59.8 +/- 2.1%, MCP-1: 42.4 +/- 3.1% and MIP-1alpha: 50.4 +/- 3.7%). Although the positive ratios for each chemokine gradually decreased according to the wound age, the mean positive ratios in groups III and IV were significantly higher than those in group I. From the forensic aspect, these chemokines are considered useful markers for wound age determination. Thus, ratios of > 50% for IL-8, > 30% for MCP-1 or > 40% for MIP-1alpha indicate a wound age of at least I day. Moreover, the combined investigation of these three chemokines can make wound age determination more objective and accurate.
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