ArticleBritish journal of pharmacology2002
AT(2) receptor-dependent vasodilation is mediated by activation of vascular kinin generation under flow conditions.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 93 citations in OpenAlex.
- Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.Biochemical pharmacology · 2024Review
- Cardioprotective Mechanisms against Reperfusion Injury in Acute Myocardial Infarction: Targeting Angiotensin II Receptors.Biomedicines · 2022Review
- The Angiotensin ATPharmacological reviews · 2022Review
- Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation.Nature reviews. Immunology · 2022Review
- Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Review
- Estrogen Receptor-β Mediates Estradiol-Induced Pregnancy-Specific Uterine Artery Endothelial Cell Angiotensin Type-2 Receptor Expression.Hypertension (Dallas, Tex. : 1979) · 2019Article
- NADPH Oxidases and Mitochondria in Vascular Senescence.International journal of molecular sciences · 2018Review
- Direct Activation of Angiotensin II Type 2 Receptors Enhances Muscle Microvascular Perfusion, Oxygenation, and Insulin Delivery in Male Rats.Endocrinology · 2018Article
- Long-term treatment of spontaneously hypertensive rats with PD123319 and electrophysiological remodeling of left ventricular myocardium.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- AT2 receptor activities and pathophysiological implications.Journal of cardiovascular pharmacology · 2015Review
- Local bone interaction between renin-angiotensin system and kallikrein-kinin system in diabetic rat.International journal of clinical and experimental pathology · 2015Article
- Bradykinin antagonist counteracts the acute effect of both angiotensin-converting enzyme inhibition and of angiotensin receptor blockade on the lower limit of autoregulation of cerebral blood flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure.Integrated blood pressure control · 2013Review
- Metabolic actions of angiotensin II and insulin: a microvascular endothelial balancing act.Molecular and cellular endocrinology · 2013Review
- The intrarenal renin-angiotensin and dopaminergic systems: control of renal sodium excretion and blood pressure.Hypertension (Dallas, Tex. : 1979) · 2013Review
- AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function.Pflugers Archiv : European journal of physiology · 2013Review
- Oxidative stress-mediated effects of angiotensin II in the cardiovascular system.World journal of hypertension · 2012Article
- Angiotensin II type-2 receptor-specific effects on the cardiovascular system.Cardiovascular diagnosis and therapy · 2012Review
- Angiotensin II receptors modulate muscle microvascular and metabolic responses to insulin in vivo.Diabetes · 2011Article
- Angiotensin II receptors and drug discovery in cardiovascular disease.Drug discovery today · 2011Review
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Physiological roles of angiotensin II type 2 receptor (AT(2)) are not well defined. This study was designed to investigate the mechanisms of AT(2)-dependent vascular relaxation by studying vasodilation in pressurized and perfused rat mesenteric arterial segments. Perfusion of angiotensin II in the presence of AT(1) antagonist elicited vascular relaxation, which was completely dependent on AT(2) receptors on endothelium. FR173657 (>1 microM), a bradykinin (BK) B(2)-specific antagonist, significantly suppressed AT(2)-dependent vasodilation (maximum inhibition: 68.5% at 10 microM). Kininogen-deficient Brown Norway Katholiek rats showed a significant reduction in AT(2)-mediated vasodilatory response compared with normal wild-type Brown Norway rats. Indomethacin (>1 microM), aprotinin (10 microM) and soybean trypsin inhibitor (10 microM) also reduced AT(2)-dependent vasodilation. Our results demonstrated that stimulation of AT(2) receptors caused a significant vasodilation through local production of BK in resistant arteries of rat mesentery in a flow-dependent manner. Such vasodilation counterbalances AT(1)-dependent vasoconstriction to regulate the vascular tone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.