ArticleJournal of neurovirology2002
Choroid plexus macrophages proliferate and release toxic factors in response to feline immunodeficiency virus.
Article in Journal of neurovirology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- M1-type polarized macrophage contributes to brain damage through CXCR3.2/CXCL11 pathways after RGNNV infection in grouper.Virulence · 2024Article
- Choroid Plexus as a Mediator of CNS Inflammation in Multiple Sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Review
- Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Macrophages at CNS interfaces: ontogeny and function in health and disease.Nature reviews. Neuroscience · 2019Review
- Current and Future Therapeutic Strategies for Lentiviral Eradication from Macrophage Reservoirs.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Review
- Culture Model for Non-human Primate Choroid Plexus.Frontiers in cellular neuroscience · 2019Article
- Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis.Frontiers in pharmacology · 2019Review
- Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration.Veterinary sciences · 2017Review
- Differential regulation of macrophage phenotype by mature and pro-nerve growth factor.Journal of neuroimmunology · 2015Article
- Transmigration of macrophages across the choroid plexus epithelium in response to the feline immunodeficiency virus.Cell and tissue research · 2012Article
- The neuropathogenesis of feline immunodeficiency virus infection: barriers to overcome.Veterinary journal (London, England : 1997) · 2011Review
- Feline immunodeficiency virus neuropathogenesis: from cats to calcium.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2007Review
- Compartmentalization and evolution of feline immunodeficiency virus between the central nervous system and periphery following intracerebroventricular or systemic inoculation.Journal of neurovirology · 2006Article
- Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery.Journal of neurovirology · 2006Article
- Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route.Pharmaceutical research · 2005Review
- Cerebrospinal fluid from human immunodeficiency virus--infected individuals facilitates neurotoxicity by suppressing intracellular calcium recovery.Journal of neurovirology · 2005Article
- Dynamics of viral and proviral loads of feline immunodeficiency virus within the feline central nervous system during the acute phase following intravenous infection.Journal of virology · 2003Article
- FIV and neuroAIDS.Journal of neurovirology · 2002Review
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6 authors at 3 institutions in 1 country.
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Abstract
Recent observations have suggested that lentiviruses stimulate the proliferation and activation of microglia. A similar effect within the dense macrophage population of the choroid plexus could have significant implications for trafficking of virus and inflammatory cells into the brain. To explore this possibility, we cultured fetal feline macrophages and examined their response to feline immunodeficiency virus (FIV) or the T-cell-derived protein, recombinant human CD40-ligand trimer (rhuCD40-L). The rhCD40-L was the most potent stimulus for macrophage proliferation, often inducing a dramatic increase in macrophage density. Exposure to FIV resulted in a small increase in the number of macrophages and macrophage nuclei labeled with bromodeoxyuridine. The increase in macrophage density after FIV infection also correlated with an increase in neurotoxic activity of the macrophage-conditioned medium. Starting at 16-18 weeks postinfection, well after the peak of viremia, a similar toxic activity was detected in cerebrospinal fluid (CSF) from FIV-infected cats. Toxicity in the CSF increased over time and was paralleled by strong CD18 staining of macrophages/microglia in the choroid plexus and adjacent parenchyma. These results suggest that lentiviral infection of the choroid plexus can induce a toxic inflammatory response that is fueled by local macrophage proliferation. Together with the observation of increasing toxic activity in the CSF and increased CD18 staining in vivo, these observations suggest that choroid plexus macrophages may contribute to an inflammatory cascade in the brain that progresses independently of systemic and CSF viral load.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.