ArticleMolecular and cellular biology2002
Cyclin D and cdk4 are required for normal development beyond the blastula stage in sea urchin embryos.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Gefitinib-coated balloon inhibits the excessive hyperplasia of intima after vascular injuries through PI3K/AKT pathway.Technology and health care : official journal of the European Society for Engineering and Medicine · 2019Article
- De novo assembly of a transcriptome from the eggs and early embryos of Astropecten aranciacus.PloS one · 2017Article
- An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo.Developmental biology · 2016Article
- Developmental control of transcriptional and proliferative potency during the evolutionary emergence of animals.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Developmental cis-regulatory analysis of the cyclin D gene in the sea urchin Strongylocentrotus purpuratus.Biochemical and biophysical research communications · 2013Article
- Runx expression is mitogenic and mutually linked to Wnt activity in blastula-stage sea urchin embryos.PloS one · 2008Article
- Calcium at fertilization and in early development.Physiological reviews · 2006Review
- Evaluation of developmental phenotypes produced by morpholino antisense targeting of a sea urchin Runx gene.BMC biology · 2004Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
cdk4 mRNA and protein are constitutively expressed in sea urchin eggs and throughout embryonic development. In contrast, cyclin D mRNA is barely detectable in eggs and early embryos, when the cell cycles consist of alternating S and M phases. Cyclin D mRNA increases dramatically in embryos at the early blastula stage and remains at a constant level throughout embryogenesis. An increase in cdk4 kinase activity occurs concomitantly with the increase in cyclin D mRNA. Ectopic expression of cyclin D mRNA in eggs arrests development before the 16-cell stage and causes eventual embryonic death, suggesting that activation of cyclin D/cdk4 in cleavage cell cycles is lethal to the embryo. In contrast, blocking cyclin D or cdk4 expression with morpholino antisense oligonucleotides results in normal development of early gastrula-stage embryos but abnormal, asymmetric larvae. These results suggest that in sea urchins, cyclin D and cdk4 are required for normal development and perhaps the patterning of the developing embryo, but may not be directly involved in regulating entry into the cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.