ArticleBiotechnology progress
pH-Sensitive hydrogels as gastrointestinal tract absorption enhancers: transport mechanisms of salmon calcitonin and other model molecules using the Caco-2 cell model.
Article in Biotechnology progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials.Polymers · 2023Review
- Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia.International journal of nanomedicine · 2017Article
- pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- An overview of clinical and commercial impact of drug delivery systems.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- pH-responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics.Journal of biomedical materials research. Part A · 2013Article
- Approaches for enhancing oral bioavailability of peptides and proteins.International journal of pharmaceutics · 2013Review
- An inulin and doxorubicin conjugate for improving cancer therapy.Journal of drug delivery science and technology · 2013Article
- pH-responsive hydrogels containing PMMA nanoparticles: an analysis of controlled release of a chemotherapeutic conjugate and transport properties.Journal of biomaterials science. Polymer edition · 2013Article
- Investigations into the fate of inhaled salmon calcitonin at the respiratory epithelial barrier.Pharmaceutical research · 2012Article
- Enhanced mucoadhesive capacity of novel co-polymers for oral protein delivery.Journal of biomaterials science. Polymer edition · 2011Article
- Application of in situ polymerization for design and development of oral drug delivery systems.AAPS PharmSciTech · 2010Review
- Assessment of poly(methacrylic acid-co-N-vinyl pyrrolidone) as a carrier for the oral delivery of therapeutic proteins using Caco-2 and HT29-MTX cell lines.Journal of biomedical materials research. Part A · 2010Article
- The effect of complexation hydrogels on insulin transport in intestinal epithelial cell models.Acta biomaterialia · 2010Article
- Impact of Absorption and Transport on Intelligent Therapeutics and Nano-scale Delivery of Protein Therapeutic Agents.Chemical engineering science · 2009Article
- Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2009Review
- Synthesis, characterization and in vivo efficacy of PEGylated insulin for oral delivery with complexation hydrogels.Pharmaceutical research · 2009Article
- Confocal microscopic analysis of transport mechanisms of insulin across the cell monolayer.International journal of pharmaceutics · 2008Article
- Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery.Biomacromolecules · 2008Article
- Novel complexation hydrogels for oral peptide delivery: in vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers.Journal of biomedical materials research. Part A · 2003Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The main interest of this work was the investigation of the transport mechanisms of salmon calcitonin through the epithelial cell monolayer in the presence and absence of pH-sensitive hydrogel nanospheres composed of poly(methacrylic acid-grafted-poly(ethylene glycol)) (PMAA-g-EG). For this purpose, a gastrointestinal cell culture model, the Caco-2 cell line, was employed. The transport of other macromolecules such as fluorescein sodium, fluorescein isothiocyanate dextran, and (14)C-mannitol were also investigated and compared. Transport experiments were conducted in the apical-to-basolateral direction at 37 and 5 degrees C and from the basolateral-to-apical direction at 37 degrees C. Results revealed that the presence of P(MAA-g-EG) nanospheres increased the transport of paracellularly transported molecules such as (14)C-mannitol and fluorescein isothiocyanate dextran when compared to controls. Fluorescein sodium salt solutions were investigated as an actively transported molecule. The transport of fluorescein was affected by the concentration of PEG chains in the structure. Salmon calcitonin transport was enhanced in the presence of the nanospheres. The comparison of the transport behavior of dextran and calcitonin revealed that the main transport mechanism for salmon calcitonin through epithelial cell monolayers is predominantly paracellular.
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