Evidence map›Paper›PMID 12050481›Full record

ArticleThe Journal of urology2002

Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941.

Charles Huggins, Clarence V Hodges

Registry-linked trialAbstract readBiographySeminal ArticleHistorical Article
PubMed Publisher
In one paragraph

Article in The Journal of urology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00490022 (The Effect of Dihydrotestosterone), which is not on this map. Cited by 375 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
375citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00490022 phase1 / phase2completednot on this mapstarted 2007, after this paper: background citation

The Effect of Dihydrotestosterone (DHT) on Prostate Tissue Androgen Concentrations and Inflammation in Normal Men

TypeinterventionalSponsorUniversity of WashingtonRan2007 to 2009Enrolled31ConditionsHealthyArmsDihydrotestosterone (DHT) gel (0.7%), Placebo gel
3 · Its place in the literature

Who cites it

375 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Reproducibility and Repeatability of SemiquantitativeJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
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  14. Intermittent versus continuous androgen deprivation therapy to biochemical recurrence after external beam radiotherapy: a phase 3 GICOR study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017
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315 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Charles Huggins
Clarence V Hodges

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acid PhosphataseAnimalsBiomarkers, TumorBone NeoplasmsCombined Modality TherapyDiethylstilbestrolDogsEstradiolEstradiol CongenersFollow-Up StudiesHistory, 20th CenturyHumansMaleOrchiectomyPrognosisProstatic NeoplasmsAcid PhosphataseBiomarkers, TumorDiethylstilbestrolEstradiolestradiol 3-benzoateEstradiol Congenersprostatic acid phosphataseProtein Tyrosine PhosphatasesTestosterone

Identifiers

PMID12050481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.