ArticleJournal of virology2002
Interleukin-1beta expression in human gastric carcinoma with Epstein-Barr virus infection.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Advances in Epstein-Barr Virus Detection: From Traditional Methods to Modern Technologies.Viruses · 2025Review
- Targeting archetypes of viral-driven cancers with immunotherapy: a perspective on immunogenicity within the tumor microenvironment.Frontiers in immunology · 2025Review
- Mechanisms of T cell evasion by Epstein-Barr virus and implications for tumor survival.Frontiers in immunology · 2023Review
- Gastric carcinoma with lymphoid stroma diagnosed by endoscopic ultrasound-guided fine-needle aspiration.Clinical journal of gastroenterology · 2021Article
- Early Pattern of Epstein-Barr Virus Infection in Gastric Epithelial Cells by "Cell-in-cell".Virologica Sinica · 2019Article
- The Microenvironment in Epstein-Barr Virus-Associated Malignancies.Pathogens (Basel, Switzerland) · 2018Review
- Elevated Levels of Interferon-Journal of immunology research · 2017Article
- In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis.Virchows Archiv : an international journal of pathology · 2016Article
- Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response.Journal of gastric cancer · 2016Review
- Hypermethylation of the interferon regulatory factor 5 promoter in Epstein-Barr virus-associated gastric carcinoma.Journal of microbiology (Seoul, Korea) · 2015Article
- Article
- Epstein-barr virus in gastric carcinoma.Cancers · 2014Review
- Epstein-Barr Virus (EBV)-associated gastric carcinoma.Viruses · 2012Review
- EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors.Nature medicine · 2008Article
- Epstein-Barr virus and gastric carcinoma: virus-host interactions leading to carcinoma.Cancer science · 2008Review
- Epstein-Barr virus and gastric carcinoma--viral carcinogenesis through epigenetic mechanisms.International journal of clinical and experimental pathology · 2008Article
- Imaging virus-associated cancer.Current pharmaceutical design · 2008Review
- Phenotype analysis by MUC2, MUC5AC, MUC6, and CD10 expression in Epstein-Barr virus-associated gastric carcinoma.Journal of gastroenterology · 2006Article
- Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus.Cancer science · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The KT tumor is a transplantable strain of a human Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC), established in severe combined immunodeficiency (SCID) mice, with which the cytokine expression of EBVaGC can be investigated without interference from the infiltrating lymphocytes. As a part of a high-density oligonucleotide array (GeneChip) analysis of EBVaGC, the interleukin-1beta (IL-1beta) gene was the only cytokine gene that showed markedly higher expression in the KT tumor cells than in two tumor strains of EBV-negative GC. The results were confirmed by Northern blotting, Western blotting, and enzyme-linked immunosorbent assay. Furthermore, we demonstrated a positive signal for IL-1beta mRNA in the carcinoma cells of a surgically resected EBVaGC, but not in EBV-negative GC, by in situ hybridization. In vitro, IL-1beta increased the cell growth of a GC cell line, TMK1. Thus, IL-1beta may act as an autocrine growth factor in EBVaGC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.