ArticleJournal of virology2002
Asymmetric requirement for cholesterol in receptor-bearing but not envelope-bearing membranes for fusion mediated by ecotropic murine leukemia virus.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts.Journal of virology · 2025Article
- Rotavirus C Replication in Porcine Intestinal Enteroids Reveals Roles for Cellular Cholesterol and Sialic Acids.Viruses · 2022Article
- Membrane Rafts: Portals for Viral Entry.Frontiers in microbiology · 2021Review
- Cellular cholesterol is required for porcine nidovirus infection.Archives of virology · 2017Article
- Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense.Current molecular pharmacology · 2017Article
- Herpes Simplex Virus 1 Envelope Cholesterol Facilitates Membrane Fusion.Frontiers in microbiology · 2017Article
- Role of the lipid rafts in the life cycle of canine coronavirus.The Journal of general virology · 2015Article
- Critical role of cellular cholesterol in bovine rotavirus infection.Virology journal · 2014Article
- Cholesterol dependence of Newcastle Disease Virus entry.Biochimica et biophysica acta · 2012Article
- Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1.The Journal of biological chemistry · 2011Article
- Cholesterol dependence of pseudorabies herpesvirus entry.Current microbiology · 2011Article
- Cholesterol is important for a post-adsorption step in the entry process of transmissible gastroenteritis virus.Antiviral research · 2010Article
- The Role of Lipids in Retrovirus Replication.Viruses · 2010Article
- Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome.Progress in lipid research · 2010Review
- Article
- Importance of cholesterol for infection of cells by transmissible gastroenteritis virus.Virus research · 2008Article
- Lipids as modulators of membrane fusion mediated by viral fusion proteins.European biophysics journal : EBJ · 2007Review
- Canine distemper virus infection requires cholesterol in the viral envelope.Journal of virology · 2007Article
- Pathogens: raft hijackers.Nature reviews. Immunology · 2003Review
- Virus entry, assembly, budding, and membrane rafts.Microbiology and molecular biology reviews : MMBR · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We show that fusion mediated by ecotropic murine leukemia virus envelope is dependent on cholesterol in receptor-bearing membranes. The effect is >10 times larger in insect cells than mammalian cells, probably because the former can be more extensively depleted of cholesterol. The fact that cholesterol is apparently not needed in envelope-bearing membranes suggests that it plays a role in an asymmetric step in membrane fusion and argues against a class of models in which cholesterol is important in symmetric fusion intermediates. The insect cell system has promise for clarifying the role of membrane rafts in other aspects of cell physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.