ArticleJournal of virology2002
Interferons mediate terminal differentiation of human cortical thymic epithelial cells.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- RNA-binding proteins Zfp36l1 and Zfp36l2 protect against premature thymic involution.Cellular & molecular immunology · 2026Article
- Article
- The Timing and Abundance of IL-2Rβ (CD122) Expression Control ThymicFrontiers in immunology · 2021Article
- Review
- The human thymus perivascular space is a functional niche for viral-specific plasma cells.Science immunology · 2016Article
- MicroRNA-205 Maintains T Cell Development following Stress by Regulating Forkhead Box N1 and Selected Chemokines.The Journal of biological chemistry · 2016Article
- Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Molecular and cellular mechanisms of Mycobacterium avium-induced thymic atrophy.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Immature CD4+CD8+ thymocytes are preferentially infected by measles virus in human thymic organ cultures.PloS one · 2012Article
- Measles virus-induced suppression of immune responses.Immunological reviews · 2010Review
- Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes.Blood · 2008Article
- Cell-cell fusion induced by measles virus amplifies the type I interferon response.Journal of virology · 2007Article
- Cytosolic 5'-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response.PloS one · 2007Article
- Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses.Virology journal · 2007Article
- Article
- The thymus is a common target organ in infectious diseases.PLoS pathogens · 2006Review
- Specific and nontoxic silencing in mammalian cells with expressed long dsRNAs.Nucleic acids research · 2006Article
- Measles virus (MV) nucleoprotein binds to a novel cell surface receptor distinct from FcgammaRII via its C-terminal domain: role in MV-induced immunosuppression.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the thymus, epithelial cells comprise a heterogeneous population required for the generation of functional T lymphocytes, suggesting that thymic epithelium disruption by viruses may compromise T-cell lymphopoiesis in this organ. In a previous report, we demonstrated that in vitro, measles virus induced differentiation of cortical thymic epithelial cells as characterized by (i) cell growth arrest, (ii) morphological and phenotypic changes, and (iii) apoptotis as a final step of this process. In the present report, we have analyzed the mechanisms involved. First, measles virus-induced differentiation of thymic epithelial cells is shown to be strictly dependent on beta interferon (IFN-beta) secretion. In addition, transfection with double-stranded RNA, a common intermediate of replication for a broad spectrum of viruses, is reported to similarly mediate thymic epithelial cell differentiation through IFN-beta induction. Finally, we demonstrated that recombinant IFN-alpha, IFN-beta, or IFN-gamma was sufficient to induce differentiation and apoptosis of uninfected thymic epithelial cells. These observations suggested that interferon secretion by either infected cells or activated leukocytes, such as plasmacytoid dendritic cells or lymphocytes, may induce thymic epithelium disruption in a pathological context. Thus, we have identified a new mechanism that may contribute to thymic atrophy and altered T-cell lymphopoiesis associated with many infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.