ArticleThe Journal of biological chemistry2002
Cloning and characterization of a calcium-binding, histamine-releasing protein from Schistosoma mansoni.
Article in The Journal of biological chemistry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 101 citations in OpenAlex.
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- Identification and characterization of a novel nematode pan allergen (NPA) from Wuchereria bancrofti and their potential role in human filarial tropical pulmonary eosinophilia (TPE).PLoS neglected tropical diseases · 2024Article
- How to train your myeloid cells: a way forward for helminth vaccines?Frontiers in immunology · 2023Review
- Effects ofInternational journal of molecular sciences · 2022Article
- Sequence Analysis and Comparison of TCTP Proteins from Human Protozoan Parasites.Acta parasitologica · 2022Article
- Schistosome immunomodulators.PLoS pathogens · 2021Review
- Behind Enemy Lines: Immunomodulatory Armamentarium of the Schistosome Parasite.Frontiers in immunology · 2020Review
- TCTP fromCells · 2019Article
- Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material.Scientific reports · 2018Article
- A novel Meloidogyne enterolobii effector MeTCTP promotes parasitism by suppressing programmed cell death in host plants.Molecular plant pathology · 2017Article
- Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma.BioMed research international · 2015Article
- Article
- Expression of translationally controlled tumor protein (TCTP) gene of Dirofilaria immitis guided by transcriptomic screening.The Korean journal of parasitology · 2014Article
- An EF-handed Ca(2+)-binding protein of Chinese liver fluke Clonorchis sinensis.Parasitology research · 2013Article
- The effect of translationally controlled tumour protein (TCTP) on programmed cell death in plants.BMC plant biology · 2013Article
- Molecular identification, immunolocalization, and characterization of Clonorchis sinensis calmodulin.Parasitology research · 2013Article
- Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein.Infection and immunity · 2012Article
- Translationally controlled tumour protein (TCTP) is present in human cornea and increases in herpetic keratitis.Diagnostic pathology · 2012Article
- Sumoylation of human translationally controlled tumor protein is important for its nuclear transport.Biochemistry research international · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A homologue of the mammalian translationally controlled tumor protein (TCTP) was cloned from the human parasite Schistosoma mansoni (SmTCTP). Sequence analysis showed that SmTCTP differed from other reported TCTPs in having only one signature sequence. Subsequently, SmTCTP was cloned in a T7 expression system and expressed as a histidine-tagged fusion protein. Recombinant SmTCTP (rSmTCTP) has a molecular mass of approximately 23 kDa with the histidine tag. Further analysis showed that SmTCTP transcripts and protein are expressed in all life cycle stages of the parasite within the vertebrate hosts. Interestingly, antibodies to SmTCTP were present in the sera of mice 9 weeks after infection with S. mansoni. Characterization studies showed that rSmTCTP is a calcium-binding protein that can cause histamine release from basophil/mast cells and induce eosinophil infiltration. These findings suggest that SmTCTP may have an important role in the development of allergic inflammatory responses associated with schistosomiasis and may be a target for new drug development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.