ArticleProceedings of the National Academy of Sciences of the United States of America2002
TAR RNA loop: a scaffold for the assembly of a regulatory switch in HIV replication.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- DMS-MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The HIV-1 Transcriptional Program: From Initiation to Elongation Control.Journal of molecular biology · 2025Review
- Variations in the Abortive HIV-1 RNA Hairpin Do Not Impede Viral Sensing and Innate Immune Responses.Pathogens (Basel, Switzerland) · 2021Article
- NMR Studies of Retroviral Genome Packaging.Viruses · 2020Review
- The Long Noncoding RNAmBio · 2019Article
- Article
- Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Modeling the Function of TATA Box Binding Protein in Transcriptional Changes Induced by HIV-1 Tat in Innate Immune Cells and the Effect of Methamphetamine Exposure.Frontiers in immunology · 2018Article
- Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells.Nucleic acids research · 2016Article
- Article
- An Evolved RNA Recognition Motif That Suppresses HIV-1 Tat/TAR-Dependent Transcription.ACS chemical biology · 2016Article
- The 57th amino acid conveys the differential subcellular localization of human immunodeficiency virus-1 Tat derived from subtype B and C.Virus genes · 2016Article
- APOBEC3G inhibits HIV-1 RNA elongation by inactivating the viral trans-activation response element.Journal of molecular biology · 2014Article
- Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.The Journal of biological chemistry · 2014Article
- Article
- In vivo SELEX of single-stranded domains in the HIV-1 leader RNA.Journal of virology · 2014Article
- Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4.Cell cycle (Georgetown, Tex.) · 2014Article
- Generation of genetically stable recombinant rotaviruses containing novel genome rearrangements and heterologous sequences by reverse genetics.Journal of virology · 2013Article
- A large-scale association study for nanoparticle C60 uncovers mechanisms of nanotoxicity disrupting the native conformations of DNA/RNA.Nucleic acids research · 2012Article
- Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging.Retrovirology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Replication of HIV requires the Tat protein, which activates elongation of RNA polymerase II transcription at the HIV-1 promoter by interacting with the cyclin T1 (CycT1) subunit of the positive transcription elongation factor complex b (P-TEFb). The transactivation domain of Tat binds directly to the CycT1 subunit of P-TEFb and induces loop sequence-specific binding of P-TEFb onto nascent HIV-1 trans-activation responsive region (TAR) RNA. We used systematic RNA-protein photocross-linking, Western blot analysis, and protein footprinting to show that residues 252-260 of CycT1 interact with one side of the TAR RNA loop and enhance interaction of Tat residue K50 to the other side of the loop. Our results show that TAR RNA provides a scaffold for two protein partners to bind and assemble a regulatory switch in HIV replication. RNA-mediated assembly of RNA-protein complexes could be a general mechanism for stable ribonucleoprotein complex formation and a key step in regulating other cellular processes and viral replication.
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