ArticleProceedings of the National Academy of Sciences of the United States of America2002
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases.MedComm · 2026Review
- Forward and Reverse Genetics of B Cell Malignancies: From Insertional Mutagenesis to CRISPR-Cas.Frontiers in immunology · 2021Review
- Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology.Oncogene · 2019Review
- The Conservation of Average Entropy Production Rate in a Model of Signal Transduction: Information Thermodynamics Based on the Fluctuation Theorem.Entropy (Basel, Switzerland) · 2018Article
- Review
- ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.Oncogene · 2016Article
- Differential requirements of cellular and humoral immune responses for Fv2-associated resistance to erythroleukemia and for regulation of retrovirus-induced myeloid leukemia development.Journal of virology · 2013Article
- In vitro murine leukemia retroviral integration and structure fluctuation of target DNA.PloS one · 2012Article
- Murine leukemia retrovirus integration induces the formation of transcription factor complexes on palindromic sequences in the signal transducer and activator of transcription factor 5a gene during the development of pre-B lymphomagenesis.The American journal of pathology · 2011Article
- Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload.The American journal of pathology · 2010Article
- Role of SV40 integration site at chromosomal interval 1q21.1 in immortalized CRL2504 cells.Cancer research · 2009Article
- Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.The Journal of experimental medicine · 2009Article
- Article
- The different functions of Stat5 and chromatin alteration through Stat5 proteins.Frontiers in bioscience : a journal and virtual library · 2008Review
- The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.Genes & development · 2008Article
- Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors.Leukemia · 2006Article
- Pre-B lymphomas in SL/Kh mice: a multifactorial disease model.Cancer science · 2003Review
- Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas.Cancer science · 2003Article
- Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.The Journal of experimental medicine · 2003Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We found that the second intron of Stat5a was one of the common integration sites of the endogenous ecotropic murine leukemia virus, i.e., SL/Kh virus integration-1 (Svi1), in early pre-B lymphomas in SL/Kh mice. The high expression of STAT5A induced by Svi1 integration and activation accelerated the transcription of its target genes such as c-Myc. Transfection of the constitutively active Stat5a mutant cDNA, but not of the wild-type cDNA, to the bone marrow cells induced colony formation of pre-B cells in a methylcellulose medium and escaped from dependence on IL-7. Such growth depended on a genetic factor in the SL/Kh strain. Consitutively high expression of Stat5a either by retrovirus integration or transfection of active mutant cDNA can be lymphomagenic to early pre-B cells in collaboration with a certain genetic background factor of mice.
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