ArticleWorld journal of gastroenterology2002
Distribution of constitutive nitric oxide synthase in the jejunum of adult rat.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats.PloS one · 2017Article
- NADPH-diaphorase expression in the rat jejunum after intestinal ischemia/reperfusion.European journal of histochemistry : EJH · 2011Article
- Extracellular arginine rapidly dilates in vivo intestinal arteries and arterioles through a nitric oxide mechanism.Microcirculation (New York, N.Y. : 1994) · 2008Article
- Activation of 5-HT3 receptors in the rat and mouse intestinal tract: a comparative study.British journal of pharmacology · 2006Article
- Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension.World journal of gastroenterology · 2004Article
- Distribution and expression of non-muscle myosin light chain kinase in rabbit livers.World journal of gastroenterology · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the distribution of the constitutive nitric oxide synthase (NOS) in the jejunum of adult rat.
methodsThe distribution of endothelial NOS (eNOS) was detected by immunohistochemistry. Immunofluorescence histochemical dual staining technique were used for studying the distribution of neuronal NOS (nNOS) and eNOS. The dual stained slides were observed under a confocal laser scanning microscope.
resultsPositive neuronal NOS (nNOS) and endothelial NOS (eNOS) cells were found to be distributed in lamina propria of villi, and the epithelial cell was not stained. eNOS was mainly located in submucosal vascular endothelia, while nNOS was mainly situated in myenteric plexus. Some cells in the villi had both nNOS and eNOS. More than 80% of the cells were positive for both nNOS and eNOS, the rest cells were positive either for nNOS or for eNOS.
conclusionThe two constitutive nitric oxide synthases are distributed differently in the jejunum of rat. nNOS distributed in myenteric plexus is a neurotransmitter in the non-adrenergic non-cholinergic (NANC) inhibitory nerves. eNOS distributed in endothelial and smooth muscle cells of blood vessels plays vasodilator role. eNOS and nNOS are coexpressed in some cells of lamina propria of villi. NO generated by those NOS is very important in the physiological and pathological process of small intestine.
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