Trial reportWorld journal of gastroenterology2002
Effect of preoperative regional artery chemotherapy on proliferation and apoptosis of gastric carcinoma cells.
Trial report in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Intravenous chemotherapy for resected gastric cancer: meta-analysis of randomized controlled trials.World journal of gastroenterology · 2002Pooled it
- Efficacy of continuous gastric artery infusion chemotherapy in relieving digestive obstruction in advanced gastric cancer.World journal of gastrointestinal oncology · 2023Article
- Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy.Cancer biology & medicine · 2023Article
- Effect of neoadjuvant chemotherapy combined with arterial chemoembolization on short-term clinical outcome of locally advanced gastric cancer.BMC cancer · 2023Article
- Combined intra-arterial and intravenous chemotherapy for unresectable, advanced gastric cancer has an improved curative effect compared with intravenous chemotherapy only.Oncology letters · 2018Article
- Evaluation of estrogen receptor expression and its relationship with clinicopathologic findings in gastric cancer.Advanced biomedical research · 2015Article
- Clinical significance of preoperative regional intra-arterial infusion chemotherapy for advanced gastric cancer.World journal of gastroenterology · 2004Article
- c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells.World journal of gastroenterology · 2004Article
- Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase and cytokine genes expressed in gastric carcinoma cell line SGC7901.World journal of gastroenterology · 2004Article
- Apoptosis-inducing effect of recombinant Caspase-3 expressed by constructed eukaryotic vector on gastric cancer cell line SGC7901.World journal of gastroenterology · 2003Article
- Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human hepatoma BEL-7402 cells.World journal of gastroenterology · 2003Article
- Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma tissues.World journal of gastroenterology · 2003Article
- Angiography for diagnosis and treatment of colorectal cancer.World journal of gastroenterology · 2003Article
- The effects of vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.World journal of gastroenterology · 2002Article
- Apoptosis of hepatoma cells SMMC-7721 induced by Ginkgo biloba seed polysaccharide.World journal of gastroenterology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effects of preoperative regional artery chemotherapy (PRACT) in inducing growth inhibition and apoptosis of gastric carcinoma (GC) cells.
methodsTUNEL (terminal-deoxynucleotidyl-transferase TdT-mediated dUTP-fluorescein and labeling) method and immunohistochemical techniques were used to detect the state of apoptosis and proliferation of GC cells in histopathologic sections. A total of 110 cases of GC and 68 cases of metastatic lymph node with or without PRACT were adopted. Correlations between apoptosis index (AI), proliferation index (PI) and PRACT and prognosis were analysed.
resultsThe apoptosis index (AI) was significantly higher in the PRACT group (12.5 +/-4.33 ) than in the untreated group (7.1 +/-3.43 , P<0.001), whereas the proliferation index (PI) in the PRACT group (33.8%+/-8.8%) was significantly lower than that in untreated group (43.6%+/-12.8%, P<0.01). Both AI and PI were correlated to the differentiation degree of GC in PRACT group, the AI in the differentiated group was higher than that in undifferentiated group (P<0.001), but the PI was lower in the differentiated group than that of the undifferentiated group (P<0.01). The AI of GC cells in metastatic lymph node was also significantly higher in the PRACT group (7.9 +/-3.41 ) than in the untreated group (3.6 +/-2.93 , P<0.01), though the PI of GC cells in metastatic lymph nodes in the PRACT group (17.2%+/-6.8%) was significantly lower than that in the untreated group (26.7%+/-9.3%, P<0.01). The severity of histopathologic changes was significantly higher in the PRACT group than in the untreated group (P<0.05). In addition, postoperative surveys demonstrated that the 5-year survival rate of GC patients in the PRACT group was significantly higher than that of patients in the untreated group (P<0.01).
conclusionPreoperative regional artery chemotherapy (PRACT) showed inhibitory action on the growth of GC cells mainly through inhibiting proliferation and inducing the apoptosis of tumor cells. PRACT can improve the progno sis of GC patients also.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.