ArticleWorld journal of gastroenterology2002
Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
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- Expression of NF-kappaB and human telomerase reverse transcriptase in gastric cancer and precancerous lesions.World journal of gastroenterology · 2004Article
- Effect of NF-kappaB, survivin, Bcl-2 and Caspase3 on apoptosis of gastric cancer cells induced by tumor necrosis factor related apoptosis inducing ligand.World journal of gastroenterology · 2004Article
- Molecule action mechanisms of NM-3 on human gastric cancer SGC-7901 cells in vivo or in vitro.World journal of gastroenterology · 2003Article
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- Isolation of a novel member of small G protein superfamily and its expression in colon cancer.World journal of gastroenterology · 2003Article
- Peroxisome proliferator-activated receptor gamma ligands inhibit cell growth and induce apoptosis in human liver cancer BEL-7402 cells.World journal of gastroenterology · 2003Article
- Expression of NGF family and their receptors in gastric carcinoma: a cDNA microarray study.World journal of gastroenterology · 2003Article
- Primary adenocarcinomas of lower esophagus, esophagogastric junction and gastric cardia: in special reference to China.World journal of gastroenterology · 2003Review
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- Expression of survivin protein in human colorectal carcinogenesis.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify whether JTE-522 can induce apoptosis in AGS cells and ROS also involved in the process, and to investigate the changes in NF-kB, p53, bcl-2 and caspase in the apoptosis process.
methodsCell culture, MTT, Electromicroscopy, agarose gel electrophoresis, lucigenin, Western blot and electrophoretic mobility shift assay (EMSA) analysis were employed to investigate the effect of JTE-522 on cell proliferation and apoptosis in AGS cells and related molecular mechanisms.
resultsJTE-522 inhibited the growth of AGS cells and induced the apoptosis. Lucigenin assay showed the generation of ROS in cells under incubation with JTE-522. The increased ROS generation might contribute to the induction of AGS cells to apoptosis. EMSA and Western blot revealed that NF-kB activity was almost completely inhibited by preventing the degradation of IkBalpha. Additionally, by using Western blot we confirmed that the level of bcl-2 was decreased, whereas p53 showed a great increase following JTE-522 treatment. Their changes were in a dose-dependent manner.
conclusionThese findings suggest that reactive oxygen species, NF-kB, p53, bcl-2 and caspase-3 may play an important role in the induction of apoptosis in AGS cells after treatment with JTE-522.
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