ArticleWorld journal of gastroenterology2002
Tumor suppressor gene p16 and Rb expression in gastric cardia precancerous lesions from subjects at a high incidence area in northern China.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Progress in immunocytochemical staining for cervical cancer screening.Cancer management and research · 2019Review
- Detection of micrometastasis of gastric carcinoma in peripheral blood circulation.World journal of gastroenterology · 2004Article
- Differences in proximal (cardia) versus distal (antral) gastric carcinogenesis via the retinoblastoma pathway.World journal of gastroenterology · 2004Article
- Primary adenocarcinomas of lower esophagus, esophagogastric junction and gastric cardia: in special reference to China.World journal of gastroenterology · 2003Review
- A gene encoding an apurinic/apyrimidinic endonuclease-like protein is up-regulated in human gastric cancer.World journal of gastroenterology · 2003Article
- Relationship between inactivation of p16 gene and gastric carcinoma.World journal of gastroenterology · 2003Article
- Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma tissues.World journal of gastroenterology · 2003Article
- Studies on microsatellite instability in p16 gene and expression of hMSH2 mRNA in human gastric cancer tissues.World journal of gastroenterology · 2003Article
- Methylation and mutation analysis of p16 gene in gastric cancer.World journal of gastroenterology · 2003Article
- HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma.World journal of gastroenterology · 2003Article
- Expression of p57kip2, Rb protein and PCNA and their relationships with clinicopathology in human pancreatic cancer.World journal of gastroenterology · 2003Article
- Association between pepsinogen C gene polymorphism and genetic predisposition to gastric cancer.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo further understand the molecular basis for gastric cardia carcinogenesis and to provide etiological clues.
methodsEndoscopic mucosa biopsy and histopathological examinations were made on 37 subjects from a high incidence area for both esophageal and gastric cardia carcinomas in northern China. All the biopsy samples were fixed in 850 ml. (-1)L alcohol and embedded in paraffin. Each block contained one piece of tissue and was serially section at 5 microm. Immunohistochemistry (ABC) was carried out on these gastric cardia samples to determine the alterations of p16 and Rb.
resultsBased on the histopathlogical examination there were 11 cases of chronic superficial gastritis, 12 cases of chronic atrophic gastritis and 14 cases of dysplasia. The immunostaining demonstrated different levels of unclear immunostaining of p16 and Rb in normal gastric cardia tissue and the tissues with different severity of lesions. With the lesions progressing, the positive immunostaining rates for p16 protein had a decreasing tendency. In contrast, the positive immunostaining rate for Rb protein had an increasing tendency. There was a significant negative relationship between the two parameters. Changes of p16 was CSG 11(100%), CAG 7(58%), DYS 4(29%) and changes of Rb was CSG 2(18%), CAG 8(67%) and DYS 12(86%), (P<0.05).
conclusionThe alterations of p16 and Rb protein may play a role in the early stages of gastric cardia carcinogenesis.
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