ArticleThe Journal of clinical investigation2002
Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia.Respiratory research · 2018Article
- Cysteinyl leukotrienes as novel host factors facilitating Cryptococcus neoformans penetration into the brain.Cellular microbiology · 2017Article
- Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j.American journal of respiratory cell and molecular biology · 2015Article
- EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling.The Journal of clinical investigation · 2015Article
- Integrative understanding of hypoxic pulmonary vasoconstriction usingIntegrative medicine research · 2014Review
- Article
- Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia.PLoS genetics · 2013Article
- Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS.American journal of physiology. Cell physiology · 2013Article
- Hemoglobin infusion does not alter murine pulmonary vascular tone.Nitric oxide : biology and chemistry · 2013Article
- Regulation of rat intrapulmonary arterial tone by arachidonic acid and prostaglandin E2 during hypoxia.PloS one · 2013Article
- Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction.The Journal of clinical investigation · 2012Article
- iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling.PloS one · 2012Article
- Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice.Anesthesiology · 2011Article
- Host cytosolic phospholipase A₂α contributes to group B Streptococcus penetration of the blood-brain barrier.Infection and immunity · 2011Article
- Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier.Infection and immunity · 2010Article
- Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- The role of peroxisome proliferator-activated receptors in pulmonary vascular disease.PPAR research · 2007Article
- Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.Hypertension (Dallas, Tex. : 1979) · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Cytosolic phospholipase A(2) (cPLA(2)) releases arachidonic acid (AA) from phospholipids in cell membranes. To assess the role of cPLA(2) in hypoxic pulmonary vasoconstriction (HPV), we measured the increase in left lung pulmonary vascular resistance (LPVR) before and during hypoxia produced by left main stem bronchus occlusion (LMBO) in mice with and without a targeted deletion of the PLA2g4a gene that encodes cPLA(2alpha). LMBO increased LPVR in cPLA(2alpha)(+/+) mice but not in cPLA(2alpha)(-/-) mice. cPLA(2alpha)(+/+) mice were better able to maintain systemic oxygenation during LMBO than were cPLA(2alpha)(-/-) mice. Administration of a cPLA(2) inhibitor, arachidonyl trifluoromethyl ketone, blocked the LMBO-induced increase in LPVR in wild-type mice, while exogenous AA restored HPV in cPLA(2alpha)(-/-) mice. Intravenous angiotensin II infusion increased PVR similarly in cPLA(2alpha)(+/+) and cPLA(2alpha)(-/-) mice. Inhibitors of cyclooxygenase or nitric oxide synthase restored HPV in cPLA(2alpha)(-/-) mice. Breathing 10% oxygen for 3 weeks produced less right ventricular hypertrophy in cPLA(2alpha)(-/-) than in cPLA(2alpha)(+/+) mice, but restored HPV in cPLA(2alpha)(-/-) mice despite the continued absence of cPLA(2) activity. These results indicate that cPLA(2) contributes to the murine pulmonary vasoconstrictor response to hypoxia. Augmenting pulmonary vascular tone restores HPV in the absence of cPLA(2) activity.
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