ArticleThe Journal of clinical investigation2002
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 76 citations in OpenAlex.
- PD-L1's Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant.Cells · 2023Review
- B Cell IL-4 Drives Th2 ResponsesFrontiers in immunology · 2022Article
- A novel model for dissecting roles of IL-17 in lung transplantation.Journal of thoracic disease · 2018Article
- Eosinophils promote inducible NOS-mediated lung allograft acceptance.JCI insight · 2017Article
- TIM-4 Identifies IFN-γ-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Heterogeneity and Stability in Foxp3+ Regulatory T Cells.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2017Review
- Elevated levels of interferon-γ production by memory T cells do not promote transplant tolerance resistance in aged recipients.PloS one · 2013Article
- Administration of a negative vaccination induces hyporesponsiveness to islet allografts.Cell transplantation · 2013Article
- Article
- CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival.PloS one · 2013Article
- Absence of MyD88 signaling induces donor-specific kidney allograft tolerance.Journal of the American Society of Nephrology : JASN · 2012Article
- Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2011Article
- Caspase inhibitor therapy synergizes with costimulation blockade to promote indefinite islet allograft survival.Diabetes · 2010Article
- Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.European journal of immunology · 2009Article
- Translating costimulation blockade to the clinic: lessons learned from three pathways.Immunological reviews · 2009Review
- Divergent role of donor dendritic cells in rejection versus tolerance of allografts.Journal of the American Society of Nephrology : JASN · 2009Article
- Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.Diabetes · 2009Article
- IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.The Journal of clinical investigation · 2008Article
- Pathophysiology of acute graft-versus-host disease: recent advances.Translational research : the journal of laboratory and clinical medicine · 2007Review
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
The Th1 cytokines IL-2 and IFN-gamma, which inhibit T cell proliferation and promote activation induced cell death, may be required to diminish alloreactive T cell numbers and to foster tolerance across full allogeneic barriers. However, we hypothesized that these cytokines might be dispensable when the alloreactive T cell clone size is relatively small, as is seen in recipients of minor-mismatched grafts. We show that alloreactive T cell clone size of C57BL/6 mice against multiple minor-mismatched 129X1/sv mice was approximately 4-9-fold smaller than that against MHC-mismatched BALB/c mice. In the MHC-mismatched combination, CD28-B7 blockade by CTLA4Ig induced long-term graft survival in wild-type recipients, but this treatment was ineffective in IFNgamma(-/-) or IL-2(-/-) recipients. In contrast, in the minor-mismatched combination, CTLA4Ig induced long-term allograft survival in wild-type, IFNgamma(-/-), and IL-2(-/-) recipients. Bcl-x(L) transgenic animals, which are defective in "passive" T cell death, are likewise sensitive to the effects of CTLA4Ig only in the setting of the minor-mismatch grafts. Therefore, the alloreactive T cell clone size is an important determinant affecting the need for Th1 cytokines and T cell death in tolerance induction. These data have implications for the design of tolerance strategies in transplant recipients with varying degrees of MHC mismatching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.