ArticleThe Journal of experimental medicine2002
A unique subset of self-specific intraintestinal T cells maintains gut integrity.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed, 231 citations in OpenAlex.
- GPR15-guided CD8Nature · 2026Article
- Lactiplantibacillus plantarum MTCC 25433 and Quercetin Blend Ameliorate Benzo[a]pyrene-Induced Gut Dysregulation in a Murine Model.Current microbiology · 2025Article
- Intestinal CD4Nature communications · 2025Article
- Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes.bioRxiv : the preprint server for biology · 2025Article
- Dynamic Changes in the Intraepithelial Lymphocyte Numbers FollowingAnimals : an open access journal from MDPI · 2024Article
- Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice.Nature communications · 2024Article
- Natural intraepithelial lymphocyte populations rise during necrotic enteritis in chickens.Frontiers in immunology · 2024Article
- Industrialized human gut microbiota increases CD8+ T cells and mucus thickness in humanized mouse gut.Gut microbes · 2023Article
- Characterization of Bovine Intraepithelial T Lymphocytes in the Gut.Pathogens (Basel, Switzerland) · 2023Article
- Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes.Clinical and experimental immunology · 2023Review
- Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor.Frontiers in immunology · 2023Review
- The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβCell death and differentiation · 2022Article
- The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8ααNature immunology · 2022Article
- Development and function of natural TCRFrontiers in immunology · 2022Review
- Peripheral and intestinal mucosal-associated invariant T cells in premature infants with necrotizing enterocolitis.Frontiers in pharmacology · 2022Article
- Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis.Frontiers in immunology · 2022Review
- Cytolytic CD4Frontiers in immunology · 2022Review
- Carnosol Maintains Intestinal Barrier Function and Mucosal Immune Homeostasis in DSS-Induced Colitis.Frontiers in nutrition · 2022Article
- CD8ααSkin health and disease · 2021Article
- Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity.Journal of leukocyte biology · 2021Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphocytes residing in the intestinal epithelium are exclusively T cells and account for one of the largest collection of T cells in the organism. However, their function remains obscure. We and others have shown that the development of intestinal intraepithelial T cells is compromised in mutant mice prone to chronic intestinal inflammation. These results led us to directly assess their role in regulating the development of colitis secondary to transfer of primary splenic TCRalphabeta(+)CD4(+)CD45RB(hi) T cells into severe combined immunodeficiency (SCID) mice. Here we demonstrate that prior reconstitution of SCID recipients with intraintestinal TCRalphabeta(+)CD4(-)CD8alpha(+)beta(-) T cells prevents disease, and does so in an interleukin (IL)-10-dependent fashion. In contrast, reconstitution with either TCRgammadelta(+) or TCRalphabeta(+)CD4(-) CD8alpha(+)beta(+) intestinal T cells did not prevent colitis. TCRalphabeta(+)CD4(-)8alpha(+)beta(-) T cells are unique to the intestinal epithelium of both rodents and humans. Previous repertoire analyses of TCRalphabeta(+)CD4(-)CD8alpha(+)beta(-) T cells revealed a high proportion of cells expressing high affinity, self-specific TCR within this subset. We demonstrate that monoclonal, self specific TCRalphabeta(+)CD4(-)CD8alpha(+)beta(-) cells derived from TCR transgenic mice also prevent the onset of colitis. Thus, intestinal TCRalphabeta(+)CD4(-)CD8alpha(+)beta(-) T cells, selected based on their self-reactivity, maintain gut integrity in a IL-10-dependent fashion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.