ArticleThe Journal of cell biology2002
Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 98 citations in OpenAlex.
- Independent roles of autophagy and apoptosis in post-apocrine-secretion cell death of salivary glands during Drosophila metamorphosis.Scientific reports · 2026Article
- CRISPR-Cas9 Genome Editing Uncovers the Mode of Action of Methoprene in the Yellow Fever Mosquito,The CRISPR journal · 2022Article
- Conceptual framework for the insect metamorphosis from larvae to pupae by transcriptomic profiling, a case study of Helicoverpa armigera (Lepidoptera: Noctuidae).BMC genomics · 2022Article
- Ecdysone controlled cell and tissue deletion.Cell death and differentiation · 2020Review
- Thin is required for cell death in the Drosophila abdominal muscles by targeting DIAP1.Cell death & disease · 2018Article
- Interactions Among Host-Parasite MicroRNAs DuringFrontiers in microbiology · 2018Article
- More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease.Cell death and differentiation · 2017Review
- Protein kinase A-mediated phosphorylation of the Broad-Complex transcription factor in silkworm suppresses its transcriptional activity.The Journal of biological chemistry · 2017Article
- Ecdysone signaling underlies the pea aphid transgenerational wing polyphenism.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Developmental Expression of Ecdysone-Related Genes Associated With Metamorphic Changes During Midgut Remodeling of Silkworm Bombyx mori (Lepidoptera:Bombycidae).Journal of insect science (Online) · 2016Article
- Cell death in development: Signaling pathways and core mechanisms.Seminars in cell & developmental biology · 2015Review
- Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1.PloS one · 2014Article
- UTX coordinates steroid hormone-mediated autophagy and cell death.Nature communications · 2013Article
- Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A/Arf locus in mesenchymal stem cells.Molecular and cellular biology · 2012Article
- Translational control by the DEAD Box RNA helicase belle regulates ecdysone-triggered transcriptional cascades.PLoS genetics · 2012Article
- Cell death by autophagy: facts and apparent artefacts.Cell death and differentiation · 2012Review
- Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster.BMC genomics · 2011Article
- Steroid-triggered, cell-autonomous death of a Drosophila motoneuron during metamorphosis.Neural development · 2011Article
- Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons.Cell death and differentiation · 2010Article
- Steroid hormone control of cell death and cell survival: molecular insights using RNAi.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The steroid hormone ecdysone regulates both cell differentiation and cell death during insect metamorphosis, by hierarchical transcriptional regulation of a number of genes, including the Broad-Complex (BR-C), the zinc finger family of transcription factors. These genes in turn regulate the transcription of a number of downstream genes. DRONC, a key apical caspase in Drosophila, is the only known caspase that is transcriptionally regulated by ecdysone during development. We demonstrate that dronc gene expression is ablated or reduced in BR-C mutant flies. Using RNA interference in an ecdysone-responsive Drosophila cell line, we show that DRONC is essential for ecdysone-mediated cell death, and that dronc upregulation in these cells is controlled by BR-C. Finally, we show that the dronc promoter has BR-C interaction sites, and that it can be transactivated by a specific isoform of BR-C. These results indicate that BR-C plays a key role in ecdysone-mediated caspase regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.