ArticleThe Journal of cell biology2002
Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 106 citations in OpenAlex.
- SCHEPHERD: A modular, programmable, direct current platform to control cell behavior.Science advances · 2026Article
- Dictyostelium discoideum chemotaxis is altered by hypoxia to orient streaming toward higher oxygen levels.BMC molecular and cell biology · 2025Article
- Electrotaxis disrupts patterns of cell-cell interactions of human corneal epithelial cells in vitro.Biophysical journal · 2025Article
- Direct current electrical fields inhibit cancer cell motility in microchannel confinements.Scientific reports · 2025Article
- Electrotaxis of Dictyostelium discoideum, Migration in an Electric Field.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The aerotaxis ofFrontiers in cell and developmental biology · 2023Article
- Article
- Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium.Cell & bioscience · 2021Article
- The Dynamics of Aerotaxis in a Simple Eukaryotic Model.Frontiers in cell and developmental biology · 2021Article
- Using Live-Cell Imaging and Synthetic Biology to Probe Directed Migration inFrontiers in cell and developmental biology · 2021Review
- Electric Fields at Breast Cancer and Cancer Cell Collective Galvanotaxis.Scientific reports · 2020Article
- Article
- Cellular velocity, electrical persistence and sensing in developed and vegetative cells during electrotaxis.PloS one · 2020Article
- Expression of integrins to control migration direction of electrotaxis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Cell migration directionality and speed are independently regulated by RasG and Gβ inBiology open · 2019Article
- Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages.PLoS biology · 2019Article
- The excitable signal transduction networks: movers and shapers of eukaryotic cell migration.The International journal of developmental biology · 2019Review
- Electric fields accelerate cell polarization and bypass myosin action in motility initiation.Journal of cellular physiology · 2018Article
- Electric Pulses Can Influence Galvanotaxis ofBioMed research international · 2018Article
- Excitable Signal Transduction Networks in Directed Cell Migration.Annual review of cell and developmental biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Cells display chemotaxis and electrotaxis by migrating directionally in gradients of specific chemicals or electrical potential. Chemotaxis in Dictyostelium discoideum is mediated by G protein-coupled receptors. The unique Gbeta is essential for all chemotactic responses, although different chemoattractants use different receptors and Galpha subunits. Dictyostelium amoebae show striking electrotaxis in an applied direct current electric field. Perhaps electrotaxis and chemotaxis share similar signaling mechanisms? Null mutation of Gbeta and cAMP receptor 1 and Galpha2 did not abolish electrotaxis, although Gbeta-null mutations showed suppressed electrotaxis. By contrast, G protein signaling plays an essential role in chemotaxis. G protein-coupled receptor signaling was monitored with PHcrac-green fluorescent protein, which translocates to inositol phospholipids at the leading edge of cells during chemotaxis. There was no intracellular gradient of this protein during electrotaxis. However, F-actin was polymerized at the leading edge of cells during electrotaxis. We conclude that reception and transduction of the electrotaxis signal are largely independent of G protein-coupled receptor signaling and that the pathways driving chemotaxis and electrotaxis intersect downstream of heterotrimeric G proteins to invoke cytoskeletal elements.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.