ArticleGenome research2002
A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- QTL analysis of modifiers for pigmentary disorder in rats carrying Ednrb sl mutations.Scientific reports · 2016Article
- Article
- Integrated cross-species transcriptional network analysis of metastatic susceptibility.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice.Journal of lipid research · 2011Article
- QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations.PloS one · 2011Article
- CDC 25A gene 263C/T, -350C/T, and -51C/G polymorphisms in breast carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2010Article
- Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.Microbiology and molecular biology reviews : MMBR · 2009Review
- Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.Virology · 2009Review
- Mouse modifier genes in mammary tumorigenesis and metastasis.Journal of mammary gland biology and neoplasia · 2008Review
- Mammary cancer susceptibility: human genes and rodent models.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Review
- Is breast cancer prognosis inherited?Breast cancer research : BCR · 2007Article
- Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.Breast cancer research : BCR · 2006Article
- Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior.Clinical & experimental metastasis · 2005Article
- Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes.Genome research · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epistatically interacting modifier loci (Apmt1 and Apmt2) accelerate the polyoma Middle-T (PyVT)-induced mammary tumor. To identify potential candidate genes loci, a combined bioinformatics and genomics strategy was used. On the basis of the assumption that the loci were functioning in the same or intersecting pathways, a search of the literature databases was performed to identify molecular pathways containing genes from both candidate intervals. Among the genes identified by this method were the cell cycle-associated genes Cdc25A and c-Myc, both of which have been implicated in breast cancer. Genomic sequencing revealed noncoding polymorphism in both genes, in the promoter region of Cdc25A, and in the 3' UTR of c-Myc. Molecular and in vitro analysis showed that the polymorphisms were functionally significant. In vivo analysis was performed by generating compound PyVT/Myc double-transgenic animals to mimic the hypothetical model, and was found to recapitulate the age-of-onset phenotype. These data suggest that c-Myc and Cdc25A are Apmt1 and Apmt2, and suggest that, at least in certain instances, bioinformatics can be utilized to bypass congenic construction and subsequent mapping in conventional QTL studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.