ArticleGenome research2002
Tandem repeats in protein coding regions of primate genes.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 97 citations in OpenAlex.
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- SATIN: a micro and mini satellite mining tool of total genome and coding regions with analysis of perfect repeats polymorphism in coding regions.BMC bioinformatics · 2024Article
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- Hidden genomic evolution in a morphospecies-The landscape of rapidly evolving genes in Tetrahymena.PLoS biology · 2019Article
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- Interrogating the "unsequenceable" genomic trinucleotide repeat disorders by long-read sequencing.Genome medicine · 2017Article
- Genetic Variation and Its Reflection on Posttranslational Modifications in Frequency Clock and Mating Type a-1 Proteins inBioMed research international · 2017Article
- Short tandem repeats in CdLS-causing genes: distribution and comparison.Journal of genetics · 2014Article
- Cross-species identification of inBioMedicine · 2014Article
- Evolution of coding microsatellites in primate genomes.Genome biology and evolution · 2013Article
- Development of ESTs and data mining of pineapple EST-SSRs.Molecular biology reports · 2012Article
- Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target.Nucleic acids research · 2012Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tandem repeats in GenBank primate nucleotide sequences annotated as protein coding regions are analyzed. It is found that only trinucleotide repeats show repeat enrichment well above the threshold of statistical significance. The statistics are improved by a simultaneous search for repeats on both the amino acid and nucleotide levels. The results of the analyses of natural sequences are interpreted by comparing them with the results of the computer simulation of the model dedicated to protein coding regions. According to the simulation results, a limited set of trinucleotides, that is, cgg, ccg, cag, and gaa repeats coding for polyalanine, polyglycine, polyproline, polyglutamine, and polylysine are prone to proliferation. It is also found that within the repeat regions slippage is more frequent by a factor of 10 than point mutations, whereas the ratio of silent versus recognizable point mutations is approximately the same as elsewhere in coding regions. The trinucleotide repeats cover slightly more than 0.3% of the protein coding regions of genes.
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