ArticleGenome research2002
Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
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- Museum of spatial transcriptomics.Nature methods · 2022Review
- Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson's disease.Translational neuroscience · 2022Article
- Article
- A genome-scale map of expression for a mouse brain section obtained using voxelation.Physiological genomics · 2007Article
- Spatial mapping of protein abundances in the mouse brain by voxelation integrated with high-throughput liquid chromatography-mass spectrometry.Genome research · 2007Article
- Microarrays and the microscope: balancing throughput with resolution.The Journal of physiology · 2006Review
- Improved peptide elution time prediction for reversed-phase liquid chromatography-MS by incorporating peptide sequence information.Analytical chemistry · 2006Article
- Adult mouse brain gene expression patterns bear an embryologic imprint.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Non-linear mapping for exploratory data analysis in functional genomics.BMC bioinformatics · 2005Article
- Investigation of different transcript quantitation tools for high-throughput mapping of brain gene expression using voxelation.Journal of molecular histology · 2004Article
- Development and evaluation of a micro- and nanoscale proteomic sample preparation method.Journal of proteome researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
To facilitate high-throughput 3D imaging of brain gene expression, a new method called voxelation has been developed. Spatially registered voxels (cubes) are analyzed, resulting in multiple volumetric maps of gene expression analogous to the images reconstructed in biomedical imaging systems. Using microarrays, 40 voxel images for 9000 genes were acquired from brains of both normal mice and mice in which a pharmacological model of Parkinson's disease (PD) had been induced by methamphetamine. Quality-control analyses established the reproducibility of the voxelation procedure. The investigation revealed a common network of coregulated genes shared between the normal and PD brain, and allowed identification of putative control regions responsible for these networks. In addition, genes involved in cell/cell interactions were found to be prominently regulated in the PD brains. Finally, singular value decomposition (SVD), a mathematical method used to provide parsimonious explanations of complex data sets, identified gene vectors and their corresponding images that distinguished between normal and PD brain structures, most pertinently the striatum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.