ArticleCellular and molecular neurobiology2001
Neuregulin induces sustained reactive oxygen species generation to mediate neuronal differentiation.
Article in Cellular and molecular neurobiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Hypoxia-inducible factor-1α: Dual roles in maintaining neuronal homeostasis and neuronal degeneration via regulation of oxidative stress, mitochondrial dynamics, and bioenergetics.Journal of physiology and biochemistry · 2026Review
- A Role for Second Messengers in Axodendritic Neuronal Polarity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Targeting redox imbalance in neurodegeneration: characterizing the role of GLP-1 receptor agonists.Theranostics · 2023Review
- Review
- Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases.Frontiers in cellular neuroscience · 2022Article
- Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone.Scientific reports · 2018Article
- Silver Nanoparticles: Two-Faced Neuronal Differentiation-Inducing Material in Neuroblastoma (SH-SY5Y) Cells.International journal of molecular sciences · 2018Article
- Regulation of neuronal development and function by ROS.FEBS letters · 2018Review
- Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis.Nature reviews. Neuroscience · 2016Review
- Article
- Neuregulin induces CTGF expression in hypertrophic scarring fibroblasts.Molecular and cellular biochemistry · 2012Article
- Reactive oxygen species and the neuronal fate.Cellular and molecular life sciences : CMLS · 2012Review
- A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function.PLoS biology · 2007Article
- Reactive oxygen species modulate the differentiation of neurons in clonal cortical cultures.Molecular and cellular neurosciences · 2006Article
- Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC.Journal of molecular neuroscience : MN · 2005Article
- ROS produced by NOX2 control in vitro development of cerebellar granule neurons development.ASN neuroArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuregulins (NRGs), which are highly expressed in the nervous system, bind and activate two receptor tyrosine kinases, ErbB-3 and ErbB-4. Recently, we have shown that ErbB-4 receptors expressed in PC12 cells mediate NRG-induced differentiation through the MAPK signaling pathway. Here we demonstrate that NRG induces an increase in the intracellular concentration of reactive oxygen species (ROS). N-acetylcysteine, a ROS scavenger, inhibited NRG-induced activation of Ras and Erk and PC12-ErbB-4 cell differentiation. These results suggest that ROS production is involved in NRG-mediated neuronal differentiation and that ROS can regulate activation of Ras and Erk. Constitutively active Ras enhanced ROS production and dominant negative Ras inhibited NRG-induced ROS production, suggesting, a positive regulatory loop between Ras and ROS. The mitogen, EGF, induced short-term ROS production whereas NRG and NGF, which induce cell differentiation, induced prolonged ROS production. These results strongly suggest that the kinetics of ROS production may determine whether the cells will differentiate or proliferate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.