ArticleThe Journal of physiology2002
Attenuated vascular responsiveness to noradrenaline release during dynamic exercise in dogs.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Inhibition of KATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle.The Journal of physiology · 2004Trial
- Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle.The Journal of physiology · 2004Trial
- Inhibition of alpha-adrenergic vasoconstriction in exercising human thigh muscles.The Journal of physiology · 2004Trial
- Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory?The Journal of physiology · 2003Trial
- alpha1- and alpha2-adrenergic vasoconstriction is blunted in contracting human muscle.The Journal of physiology · 2003Trial
- Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle?The Journal of physiology · 2002Trial
- A critical assessment of sympathetic restraint in submaximal exercise: Implications for integrated cardiovascular circuit control in exercise.Experimental physiology · 2025Review
- Does sympathetic vasoconstriction contribute to metabolism: Perfusion matching in exercising skeletal muscle?Frontiers in physiology · 2022Review
- Sex differences in the vascular response to sympathetic activation during acute hypoxaemia.Experimental physiology · 2021Article
- Cardiovascular Reflexes Activity and Their Interaction during Exercise.BioMed research international · 2015Review
- Short-term exercise training augments 2-adrenoreceptor-mediated sympathetic vasoconstriction in resting and contracting skeletal muscle.The Journal of physiology · 2013Article
- Short-term exercise training enhances functional sympatholysis through a nitric oxide-dependent mechanism.The Journal of physiology · 2013Article
- Taming the "sleeping giant": the role of endothelin-1 in the regulation of skeletal muscle blood flow and arterial blood pressure during exercise.American journal of physiology. Heart and circulatory physiology · 2013Article
- α-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg.The Journal of physiology · 2010Article
- Disparity in regional and systemic circulatory capacities: do they affect the regulation of the circulation?Acta physiologica (Oxford, England) · 2010Review
- Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscle.The Journal of physiology · 2008Article
- Systemic hypoxia and vasoconstrictor responsiveness in exercising human muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2006Article
- Carotid baroreflex control of leg vasculature in exercising and non-exercising skeletal muscle in humans.The Journal of physiology · 2004Article
- Having it both ways? Vasoconstriction in contracting muscles.The Journal of physiology · 2003Article
- Arm blood flow and oxygenation on the transition from arm to combined arm and leg exercise in humans.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During dynamic exercise, there is reduced responsiveness to alpha(1)- and alpha(2)-adrenergic receptor agonists in skeletal muscle vasculature. However, it is desirable to examine the sympathetic responsiveness to endogenous release of neurotransmitter, since exogenous sympathomimetic agents are dependent upon their ability to reach the abluminal receptor. Therefore, to further our understanding of sympathetic control of vasomotor tone during exercise, we employed a technique that would elicit the release of endogenous noradrenaline (norepinephrine) during dynamic exercise. Mongrel dogs (n = 8, 19-24 kg) were instrumented chronically with transit time ultrasound flow probes on both external iliac arteries. A catheter was placed in a side branch of the femoral artery for intra-arterial administration of tyramine, an agent which displaces noradrenaline from the nerve terminal. Doses of 0.5, 1.0 and 3.0 microg ml(-1) min(-1) of iliac blood flow were infused for 1 min at rest and during graded intensities of exercise. Dose-related decreases in iliac vascular conductance were achieved with these concentrations of tyramine. The reductions in iliac vascular conductance (means +/- S.E.M.) were 45 +/- 6 %, 30 +/- 4 %, 26 +/- 3 % and 17 +/- 2 %, for the 1.0 microg ml(-1) min(-1) dose at rest, 3.0 miles h(-1), 6.0 miles h(-1) and 6.0 miles h(-1), 10 % gradient, respectively. At all doses, the magnitude of vasoconstriction caused by administration of tyramine was inversely related to workload. We conclude that there is a reduced vascular responsiveness to sympathoactivation in dynamically exercising skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.