Evidence map›Paper›PMID 12042366›Full record

Trial reportThe Journal of physiology2002

Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle?

Michael E Tschakovsky, Kittiphong Sujirattanawimol, Stephen B Ruble, Zoran Valic, Michael J Joyner

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 183 citations in OpenAlex.

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  6. Prolonged adenosine triphosphate infusion and exercise hyperemia in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2016
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  9. Effect of vitamin C on hyperoxia-induced vasoconstriction in exercising skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2014
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  10. Alpha-adrenergic control of blood flow during exercise: effect of sex and menstrual phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2010
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  11. Intradermal administration of ATP does not mitigate tyramine-stimulated vasoconstriction in human skin.American journal of physiology. Regulatory, integrative and comparative physiology · 2010
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Michael E TschakovskySchool of Physical and Health Education, Queen's University, Kingston, ON, Canada K7L 3N6. mt29@post.queensu.ca
Kittiphong Sujirattanawimol
Stephen B Ruble
Zoran Valic
Michael J Joyner
Mayo Clinic · USMedical College of Wisconsin · USQueen's University · CA

Funding

ZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4M
ELECTRODE ARRAYS BASED ON THIN FILM TECHNOLOGYN01NS032352 · NINDS · STANFORD UNIVERSITY · PI WHITE, ROBERT L · 1985 to 1985
–
NCRR NIH HHS M01 RR000585NCRR NIH HHS RR00585NHLBI NIH HHS HL43695NINDS NIH HHS N01 NS032352
6 · The paper itself

Abstract

Sympathetic vasoconstriction of muscle vascular beds is important in the regulation of systemic blood pressure. However, vasoconstriction during exercise can also compromise blood flow support of muscle metabolism. This study tested the hypothesis that local factors in exercising muscle blunt vessel responsiveness to sympathetic vasoconstriction. We performed selective infusions of three doses of tyramine into the brachial artery (n = 8) to evoke endogenous release of noradrenaline (norepinephrine) at rest and during moderate and heavy rhythmic handgrip exercise. In separate experiments, tyramine was administered during two doses of adenosine infusion (n = 7) and two doses of sodium nitroprusside (SNP) infusion (n = 8). Vasoconstrictor effectiveness across conditions was assessed as the percentage reduction in forearm vascular conductance (FVC), calculated from invasive blood pressure and non-invasive Doppler ultrasound blood flow measurements at the brachial artery. Tyramine evoked a similar dose-dependent vasoconstriction at rest in all three groups, with the highest dose resulting in a 42-46 % reduction in FVC. This vasoconstriction was blunted with increasing exercise intensity (e.g. tyramine high dose percentage reduction in FVC; rest -43.4 +/- 3.7 %, moderate exercise -27.5 +/- 2.3 %, heavy exercise -16.7 +/- 3.6 %; P < 0.05). In contrast, tyramine infusion resulted in a greater percentage reduction in FVC during both doses of adenosine vs. rest (P < 0.05). Finally, percentage change in FVC was greater during low dose SNP infusion vs. rest (P < 0.05), but not different from rest at the high dose of SNP infusion (P = 0.507). A blunted percentage reduction in FVC during endogenous noradrenaline release in exercise but not vasodilator infusion indicates that sympathetic vasoconstriction is blunted in exercising muscle. This blunting appears to be exercise intensity-dependent.

Indexed as

AdenosineAdultBrachial ArteryExerciseForearmHumansMaleMuscle, SkeletalNorepinephrineRegional Blood FlowSympathetic Nervous SystemSympatholyticsVascular ResistanceVasoconstrictionVasodilationAdenosineNorepinephrineSympatholytics

Identifiers

PMID12042366
PMCPMC2290331
OpenAlexW2160900475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.