ArticleThe Journal of physiology2002
Serotonin suppresses the slow afterhyperpolarization in rat intralaminar and midline thalamic neurones by activating 5-HT(7) receptors.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Elevated 5-HTR7 deteriorates dysregulated megakaryocytopoiesis in immune thrombocytopenic purpura via upregulating the PKA/Orai1/ERK1/2 pathway.Haematologica · 2025Article
- Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- MULTIPLE DISTINCT TIMESCALES OF RAPID SENSORY ADAPATION IN THE THALAMOCORTICAL CIRCUIT.bioRxiv : the preprint server for biology · 2024Article
- Serotonergic 5-HTCurrent neuropharmacology · 2023Review
- Developments in FRET- and BRET-Based Biosensors.Micromachines · 2022Review
- 5-HTFrontiers in molecular neuroscience · 2022Article
- Disruption to the 5-HTNeurochemical research · 2018Article
- Efferent Vestibular Neurons Show Homogenous Discharge Output But Heterogeneous Synaptic Input Profile In Vitro.PloS one · 2015Article
- Intrinsic properties and neuropharmacology of midline paraventricular thalamic nucleus neurons.Frontiers in behavioral neuroscience · 2014Review
- Thalamic neuromodulation and its implications for executive networks.Frontiers in neural circuits · 2014Review
- 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders.Frontiers in cellular neuroscience · 2014Review
- cAMP signaling microdomains and their observation by optical methods.Frontiers in cellular neuroscience · 2014Review
- Control of sleep and wakefulness.Physiological reviews · 2012Review
- VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
- Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Mechanisms underlying spontaneous patterned activity in developing neural circuits.Nature reviews. Neuroscience · 2010Review
- Ca(2+) signaling by T-type Ca(2+) channels in neurons.Pflugers Archiv : European journal of physiology · 2009Review
- Imaging second messenger dynamics in developing neural circuits.Developmental neurobiology · 2008Review
- Dynamics of protein kinase A signaling at the membrane, in the cytosol, and in the nucleus of neurons in mouse brain slices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex.The Journal of physiology · 2005Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the highest expression level of 5-HT(7) receptors in the brain is observed in intralaminar and midline thalamic neurones, the physiological role of these receptors in this structure is unknown. In vivo recordings have shown that stimulation of the serotonergic raphe nuclei can alter the response of these neurones to a nociceptive stimulus, suggesting that serotonin modulates their firing properties. Using the patch-clamp technique in rat thalamic brain slices, we demonstrate that activation of 5-HT(7) receptors can strongly modulate the excitability of intralaminar and midline thalamic neurones by inhibiting the calcium-activated potassium conductance that is responsible for the slow afterhyperpolarization (sAHP) following a spike discharge. This sAHP was inhibited after activation of the cAMP pathway, either by bath application of forskolin or intracellular perfusion with 8-bromo-cAMP. The inhibitory effect of 5-HT(7) receptors on sAHPs was blocked by the protein kinase A antagonist R(P)-cAMPS. Calcium-imaging experiments showed no change in intracellular calcium levels during the 5-HT(7) response, indicating that in these neurones, a global calcium signal was not necessary to activate the cAMP cascade. Finally, bath application of serotonin produced a strong increase in cytosolic cAMP concentration, as measured using the fluorescent probe FlCRhR, and an inhibition of the sAHP. Taken together, these results suggest that 5-HT(7) receptors are implicated in the effect of 5-HT on sAHP in intralaminar and midline thalamic neurones, an effect that is mediated by the cAMP second-messenger cascade.
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