ArticleThe Journal of physiology2002
Functional roles of presynaptic GABA(A) receptors on glycinergic nerve terminals in the rat spinal cord.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 97 citations in OpenAlex.
- Central terminals of primary afferents coordinate the spontaneous activity of dorsal horn neurons.The Journal of physiology · 2025Article
- Presynaptic gating of monkey proprioceptive signals for proper motor action.Nature communications · 2023Article
- Extrasynaptic αJournal of neurophysiology · 2018Article
- GABAPflugers Archiv : European journal of physiology · 2018Review
- Effects of Etomidate on GABAergic and Glutamatergic Transmission in Rat Thalamocortical Slices.Neurochemical research · 2016Article
- Modulation of spontaneous intracellular Ca²⁺ fluctuations and spontaneous cholinergic transmission in rat chromaffin cells in situ by endogenous GABA acting on GABAA receptors.Pflugers Archiv : European journal of physiology · 2016Article
- Muscarinic M1 receptors regulate propofol modulation of GABAergic transmission in rat ventrolateral preoptic neurons.Journal of molecular neuroscience : MN · 2015Article
- Presynaptic glycine receptors increase GABAergic neurotransmission in rat periaqueductal gray neurons.Neural plasticity · 2013Article
- 5-HT(1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons.British journal of pharmacology · 2012Article
- Modulation of presynaptic GABA(A) receptors by endogenous neurosteroids.British journal of pharmacology · 2011Article
- Two distinct and activity-dependent mechanisms contribute to autoreceptor-mediated inhibition of GABAergic afferents to hilar mossy cells.The Journal of physiology · 2010Article
- Differential control of two forms of glutamate release by group III metabotropic glutamate receptors at rat entorhinal synapses.Neuroscience · 2007Article
- Presynaptic GABAA receptors facilitate GABAergic transmission to dopaminergic neurons in the ventral tegmental area of young rats.The Journal of physiology · 2007Article
- Distinct profiles of refilling of inhibitory neurotransmitters into presynaptic terminals projecting to spinal neurones in immature rats.The Journal of physiology · 2004Article
- Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons.The Journal of physiology · 2003Article
- Development of nociceptive synaptic inputs to the neonatal rat dorsal horn: glutamate release by capsaicin and menthol.The Journal of physiology · 2003Article
- GABAergic synapses made by a retinal dopaminergic neuron.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABA(A) receptor-mediated presynaptic depolarization is believed to induce presynaptic inhibition of excitatory synaptic transmission. We report here the functional roles of presynaptic GABA(A) receptors in glycinergic transmission of the rat spinal cord. In mechanically dissociated rat sacral dorsal commissural nucleus (SDCN) neurons attached with native glycinergic and GABAergic nerve terminals, glycinergic spontaneous inhibitory postsynaptic currents (sIPSCs) were isolated from a mixture of both glycinergic and GABAergic sIPSCs by perfusing the SDCN nerve cell body with ATP-free internal solution. Under such experimental conditions, exogenously applied muscimol (0.5 microM) depolarized glycinergic presynaptic nerve terminals and significantly increased glycinergic sIPSC frequency to 542.7 +/- 47.3 % of the control without affecting the mean current amplitude. The facilitatory effect of muscimol on sIPSC frequency was completely blocked by bicuculline (10 microM) or SR95531 (10 microM), selective GABA(A) receptor antagonists. This muscimol-induced presynaptic depolarization was due to a higher intraterminal Cl(-) concentration, which is maintained by a bumetanide-sensitive Na-K-Cl cotransporter. On the contrary, when electrically evoked, this muscimol-induced presynaptic depolarization was found to decrease the action potential-dependent glycine release evoked by focal stimulation of a single terminal. The results suggest that GABA(A) receptor-mediated presynaptic depolarization has two functional roles: (1) presynaptic inhibition of action potential-driven glycinergic transmission, and (2) presynaptic facilitation of spontaneous glycinergic transmission.
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